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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3617
Target Type SINGLE PROTEIN
Preferred Name G1/S-specific cyclin E1
Synonyms CCNE | CCNE1 | G1/S-specific cyclin-E1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • other cytosolic protein

Target Components

Component Description Relationship Accession
G1/S-specific cyclin-E1 SINGLE PROTEIN P24864

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111444 CDK3/cyclin E PROTEIN COMPLEX GROUP
CHEMBL2094126 Cyclin-dependent kinase 2/cyclin E PROTEIN COMPLEX
CHEMBL3038468 CDK1/Cyclin E PROTEIN COMPLEX
CHEMBL3038471 CDK3/Cyclin E PROTEIN COMPLEX
CHEMBL1907605 Cyclin-dependent kinase 2/cyclin E1 PROTEIN COMPLEX
CHEMBL3885554 Cyclin-dependent kinase 4/G1/S-specific cyclin-E1 PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000105173
Ensembl ENSG00000105173
GO Cellular Component GO:0000307 (cyclin-dependent protein kinase holoenzyme complex)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005829 (cytosol)
GO:0097134 (cyclin E1-CDK2 complex)
GO Molecular Function GO:0003713 (transcription coactivator activity)
GO:0005515 (protein binding)
GO:0016301 (kinase activity)
GO:0016538 (cyclin-dependent protein serine/threonine kinase regulator activity)
GO:0019901 (protein kinase binding)
GO:0050681 (androgen receptor binding)
GO Biological Process GO:0000082 (G1/S transition of mitotic cell cycle)
GO:0000083 (regulation of transcription involved in G1/S transition of mitotic cell cycle)
GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0000723 (telomere maintenance)
GO:0006270 (DNA replication initiation)
GO:0006468 (protein phosphorylation)
GO:0007049 (cell cycle)
GO:0007129 (synapsis)
GO:0016055 (Wnt signaling pathway)
GO:0030521 (androgen receptor signaling pathway)
GO:0045859 (regulation of protein kinase activity)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0051301 (cell division)
GO:0051726 (regulation of cell cycle)
GO:0070192 (chromosome organization involved in meiotic cell cycle)
GO:1903827 (regulation of cellular protein localization)
Wikipedia Cyclin_E1

Target Cross References - Protein

canSAR P24864
Human Protein Atlas ENSG00000105173
IntAct P24864
Open Targets ENSG00000105173
PharmGKB PA96
Reactome R-HSA-1538133 (G0 and Early G1.)
R-HSA-187577 (SCF(Skp2)-mediated degradation of p27/p21.)
R-HSA-2559586 (DNA Damage/Telomere Stress Induced Senescence.)
R-HSA-390471 (Association of TriC/CCT with target proteins during biosynthesis.)
R-HSA-539107 (Activation of E2F1 target genes at G1/S.)
R-HSA-6804116 (TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest.)
R-HSA-69200 (Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes.)
R-HSA-69202 (Cyclin E associated events during G1/S transition.)
R-HSA-69563 (p53-Dependent G1 DNA Damage Response.)
R-HSA-8849470 (PTK6 Regulates Cell Cycle.)
UniProt A8K684 P24864 Q14091 Q8NFG1 Q92501 Q9UD21

Target Cross References - Domain

InterPro IPR004367 (Cyclin_C-dom.)
IPR006671 (Cyclin_N.)
IPR013763 (Cyclin-like.)
IPR028858 (Cyclin_E.)
IPR036915 (Cyclin-like_sf.)
Pfam PF00134 (Cyclin_N)
PF02984 (Cyclin_C)

Target Cross References - Structure

PDBe 1W98 5L2W
CREDO 1W98 5L2W
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