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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3610
Target Type SINGLE PROTEIN
Preferred Name G1/S-specific cyclin D1
Synonyms B-cell lymphoma 1 protein | BCL-1 | BCL-1 oncogene | BCL1 | CCND1 | G1/S-specific cyclin-D1 | PRAD1 | PRAD1 oncogene
Organism Homo sapiens
Species Group No
Protein Target Classification
  • other cytosolic protein

Target Components

Component Description Relationship Accession
G1/S-specific cyclin-D1 SINGLE PROTEIN P24385

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2095942 Cyclin-dependent kinase 4/cyclin D PROTEIN COMPLEX
CHEMBL1907601 Cyclin-dependent kinase 4/cyclin D1 PROTEIN COMPLEX
CHEMBL2111455 CDK6/cyclin D1 PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000110092
Ensembl ENSG00000110092
GO Cellular Component GO:0000307 (cyclin-dependent protein kinase holoenzyme complex)
GO:0005654 (nucleoplasm)
GO:0005829 (cytosol)
GO:0016020 (membrane)
GO Molecular Function GO:0019901 (protein kinase binding)
GO Biological Process GO:0000080 (G1 phase of mitotic cell cycle)
GO:0000082 (G1/S transition of mitotic cell cycle)
GO:0000084 (S phase of mitotic cell cycle)
GO:0001934 (positive regulation of protein phosphorylation)
GO:0031571 (mitotic cell cycle G1/S transition DNA damage checkpoint)
GO:0042493 (response to drug)
GO:0045737 (positive regulation of cyclin-dependent protein kinase activity)
GO:0051301 (cell division)
GO:0070141 (response to UV-A)
Wikipedia Cyclin_D1

Target Cross References - Protein

canSAR P24385
Human Protein Atlas ENSG00000110092
IntAct P24385
PharmGKB PA75
Reactome REACT_152 (Cell Cycle, Mitotic.)
UniProt P24385 Q6LEF0

Target Cross References - Domain

InterPro IPR004367 (Cyclin_C.)
IPR006671 (Cyclin_N.)
IPR013763 (Cyclin-like.)
IPR014400 (Cyclin_A/B/D/E.)
Pfam PF00134 (Cyclin_N)
PF02984 (Cyclin_C)

Target Cross References - Structure

PDBe 2W96 2W99 2W9F 2W9Z
CREDO 2W96 2W99 2W9F 2W9Z
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