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Target Report Card

Target Name and Classification

Target ID CHEMBL3610
Preferred Name G1/S-specific cyclin D1
Synonyms B-cell lymphoma 1 protein | BCL-1 oncogene | BCL-1 | BCL1 | CCND1 | G1/S-specific cyclin-D1 | PRAD1 oncogene | PRAD1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • other cytosolic protein

Target Components

Component Description Relationship Accession
G1/S-specific cyclin-D1 SINGLE PROTEIN P24385

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3885551 Cyclin-dependent kinase 1/G1/S-specific cyclin-D1 PROTEIN COMPLEX
CHEMBL1907601 Cyclin-dependent kinase 4/cyclin D1 PROTEIN COMPLEX
CHEMBL2095942 Cyclin-dependent kinase 4/cyclin D PROTEIN COMPLEX
CHEMBL3885552 Cyclin-dependent kinase 2/G1/S-specific cyclin-D1 PROTEIN COMPLEX

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1206245 BRICICLIB G1/S-specific cyclin D1 inhibitor 1 Other PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000110092
Ensembl ENSG00000110092
GO Cellular Component GO:0000307 (cyclin-dependent protein kinase holoenzyme complex)
GO:0005622 (intracellular)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005923 (bicellular tight junction)
GO:0016020 (membrane)
GO:0017053 (transcriptional repressor complex)
GO Molecular Function GO:0003714 (transcription corepressor activity)
GO:0004672 (protein kinase activity)
GO:0004693 (cyclin-dependent protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0008134 (transcription factor binding)
GO:0016301 (kinase activity)
GO:0016538 (cyclin-dependent protein serine/threonine kinase regulator activity)
GO:0019899 (enzyme binding)
GO:0019901 (protein kinase binding)
GO:0042826 (histone deacetylase binding)
GO:0044877 (macromolecular complex binding)
GO:0070064 (proline-rich region binding)
GO Biological Process GO:0000082 (G1/S transition of mitotic cell cycle)
GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0000320 (re-entry into mitotic cell cycle)
GO:0001889 (liver development)
GO:0001934 (positive regulation of protein phosphorylation)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006367 (transcription initiation from RNA polymerase II promoter)
GO:0006468 (protein phosphorylation)
GO:0006974 (cellular response to DNA damage stimulus)
GO:0007049 (cell cycle)
GO:0007595 (lactation)
GO:0008284 (positive regulation of cell proliferation)
GO:0010033 (response to organic substance)
GO:0010039 (response to iron ion)
GO:0010165 (response to X-ray)
GO:0010243 (response to organonitrogen compound)
GO:0010971 (positive regulation of G2/M transition of mitotic cell cycle)
GO:0014070 (response to organic cyclic compound)
GO:0016055 (Wnt signaling pathway)
GO:0019221 (cytokine-mediated signaling pathway)
GO:0030178 (negative regulation of Wnt signaling pathway)
GO:0030857 (negative regulation of epithelial cell differentiation)
GO:0030968 (endoplasmic reticulum unfolded protein response)
GO:0031100 (organ regeneration)
GO:0031571 (mitotic G1 DNA damage checkpoint)
GO:0032026 (response to magnesium ion)
GO:0032355 (response to estradiol)
GO:0033197 (response to vitamin E)
GO:0033327 (Leydig cell differentiation)
GO:0033598 (mammary gland epithelial cell proliferation)
GO:0033601 (positive regulation of mammary gland epithelial cell proliferation)
GO:0042493 (response to drug)
GO:0043627 (response to estrogen)
GO:0044321 (response to leptin)
GO:0045444 (fat cell differentiation)
GO:0045471 (response to ethanol)
GO:0045737 (positive regulation of cyclin-dependent protein serine/threonine kinase activity)
GO:0045787 (positive regulation of cell cycle)
GO:0048545 (response to steroid hormone)
GO:0051301 (cell division)
GO:0051384 (response to glucocorticoid)
GO:0051412 (response to corticosterone)
GO:0051592 (response to calcium ion)
GO:0051726 (regulation of cell cycle)
GO:0060070 (canonical Wnt signaling pathway)
GO:0060749 (mammary gland alveolus development)
GO:0070141 (response to UV-A)
GO:0071157 (negative regulation of cell cycle arrest)
GO:0071310 (cellular response to organic substance)
GO:0097421 (liver regeneration)
GO:2000045 (regulation of G1/S transition of mitotic cell cycle)
Wikipedia Cyclin_D1

Target Cross References - Protein

canSAR P24385
Human Protein Atlas ENSG00000110092
IntAct P24385
Open Targets ENSG00000110092
PharmGKB PA75
Reactome R-HSA-187577 (SCF(Skp2)-mediated degradation of p27/p21.)
R-HSA-1912408 (Pre-NOTCH Transcription and Translation.)
R-HSA-3214858 (RMTs methylate histone arginines.)
R-HSA-6785807 (Interleukin-4 and 13 signaling.)
R-HSA-69229 (Ubiquitin-dependent degradation of Cyclin D1.)
R-HSA-69231 (Cyclin D associated events in G1.)
R-HSA-8849470 (PTK6 Regulates Cell Cycle.)
R-HSA-8878166 (Transcriptional regulation by RUNX2.)
R-HSA-8934593 (Regulation of RUNX1 Expression and Activity.)
R-HSA-8951430 (RUNX3 regulates WNT signaling.)
R-HSA-8951936 (RUNX3 regulates p14-ARF.)
UniProt P24385 Q6LEF0

Target Cross References - Domain

InterPro IPR004367 (Cyclin_C-dom.)
IPR006671 (Cyclin_N.)
IPR013763 (Cyclin-like.)
IPR015451 (Cyclin_D.)
IPR036915 (Cyclin-like_sf.)
Pfam PF00134 (Cyclin_N)
PF02984 (Cyclin_C)

Target Cross References - Structure

PDBe 2W96 2W99 2W9F 2W9Z
CREDO 2W96 2W99 2W9F 2W9Z