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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3595
Target Type SINGLE PROTEIN
Preferred Name Glutamate receptor ionotropic, AMPA 3
Synonyms Object
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > ligand-gated ion channel > ionotropic glutamate receptor > ampa receptor

Target Components

Component Description Relationship Accession
Glutamate receptor 3 SINGLE PROTEIN P42263

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2096670 Glutamate receptor ionotropic AMPA PROTEIN COMPLEX GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000125675
Ensembl ENSG00000125675
GO Cellular Component GO:0005654 (nucleoplasm)
GO:0030666 (endocytic vesicle membrane)
GO:0032281 (AMPA glutamate receptor complex)
GO:0045211 (postsynaptic membrane)
GO:0030425 (dendrite)
GO:0005886 (plasma membrane)
GO:0030054 (cell junction)
GO Molecular Function GO:0005234 (extracellular-glutamate-gated ion channel activity)
GO:0004971 (AMPA glutamate receptor activity)
GO Biological Process GO:0007215 (glutamate receptor signaling pathway)
GO:0035249 (synaptic transmission, glutamatergic)
GO:0007268 (synaptic transmission)
GO:0035235 (ionotropic glutamate receptor signaling pathway)
GO:0006810 (transport)
GO:0034220 (ion transmembrane transport)
Wikipedia GRIA3

Target Cross References - Protein

canSAR P42263
CGD Mental retardation, X-linked 94
Human Protein Atlas ENSG00000125675
Guide to Pharmacology 446 (GluA3)
PharmGKB PA28968
UniProt P42263 Q9HDA1 Q4VXD5 Q4VXD6 Q9HDA0 Q9HDA2 D3DTF1

Target Cross References - Domain

InterPro IPR019594 (Glu/Gly-bd.)
IPR001320 (Iontro_rcpt.)
IPR001508 (Iono_rcpt_met.)
IPR001828 (ANF_lig-bd_rcpt.)
IPR028082 (Peripla_BP_I.)
Pfam PF01094 (ANF_receptor)
PF00060 (Lig_chan)
PF10613 (Lig_chan-Glu_bd)
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