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Target Report Card

Target Name and Classification

Target ID CHEMBL3595
Preferred Name Glutamate receptor ionotropic, AMPA 3
Synonyms AMPA-selective glutamate receptor 3 | GLUR3 | GLURC | GRIA3 | GluA3 | GluR-3 | GluR-C | GluR-K3 | Glutamate receptor 3 | Glutamate receptor ionotropic, AMPA 3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > ligand-gated ion channel > ionotropic glutamate receptor > ampa receptor

Target Components

Component Description Relationship Accession
Glutamate receptor 3 SINGLE PROTEIN P42263

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2096670 Glutamate receptor ionotropic AMPA PROTEIN COMPLEX GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000125675
Ensembl ENSG00000125675
GO Cellular Component GO:0005654 (nucleoplasm)
GO:0005886 (plasma membrane)
GO:0014069 (postsynaptic density)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030054 (cell junction)
GO:0030425 (dendrite)
GO:0030666 (endocytic vesicle membrane)
GO:0032279 (asymmetric synapse)
GO:0032281 (AMPA glutamate receptor complex)
GO:0043025 (neuronal cell body)
GO:0043083 (synaptic cleft)
GO:0043195 (terminal bouton)
GO:0043197 (dendritic spine)
GO:0043198 (dendritic shaft)
GO:0043204 (perikaryon)
GO:0045202 (synapse)
GO:0045211 (postsynaptic membrane)
GO Molecular Function GO:0004872 (receptor activity)
GO:0004970 (ionotropic glutamate receptor activity)
GO:0004971 (AMPA glutamate receptor activity)
GO:0005216 (ion channel activity)
GO:0005231 (excitatory extracellular ligand-gated ion channel activity)
GO:0005234 (extracellular-glutamate-gated ion channel activity)
GO Biological Process GO:0006810 (transport)
GO:0006811 (ion transport)
GO:0007215 (glutamate receptor signaling pathway)
GO:0007268 (chemical synaptic transmission)
GO:0034220 (ion transmembrane transport)
GO:0035235 (ionotropic glutamate receptor signaling pathway)
GO:0060992 (response to fungicide)
Wikipedia GRIA3

Target Cross References - Protein

canSAR P42263
CGD Mental retardation, X-linked 94
Human Protein Atlas ENSG00000125675
Guide to Pharmacology 446
Open Targets ENSG00000125675
PharmGKB PA28968
Pharos P42263 (Tclin)
Reactome R-HSA-399710 (Activation of AMPA receptors.)
R-HSA-399719 (Trafficking of AMPA receptors.)
R-HSA-416993 (Trafficking of GluR2-containing AMPA receptors.)
R-HSA-438066 (Unblocking of NMDA receptor, glutamate binding and activation.)
R-HSA-8849932 (SALM protein interactions at the synapses.)
UniProt D3DTF1 P42263 Q4VXD5 Q4VXD6 Q9HDA0 Q9HDA1 Q9HDA2 Q9P0H1

Target Cross References - Domain

InterPro IPR001320 (Iontro_rcpt.)
IPR001508 (Iono_rcpt_met.)
IPR001828 (ANF_lig-bd_rcpt.)
IPR019594 (Glu/Gly-bd.)
IPR028082 (Peripla_BP_I.)
Pfam PF00060 (Lig_chan)
PF01094 (ANF_receptor)
PF10613 (Lig_chan-Glu_bd)