ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL3594
Target Type SINGLE PROTEIN
Preferred Name Carbonic anhydrase IX
Synonyms CA-IX | CA9 | CAIX | Carbonate dehydratase IX | Carbonic anhydrase 9 | Carbonic anhydrase IX | G250 | MN | Membrane antigen MN | P54/58N | RCC-associated antigen G250 | Renal cell carcinoma-associated antigen G250 | pMW1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > lyase

Target Components

Component Description Relationship Accession
Carbonic anhydrase 9 SINGLE PROTEIN Q16790

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2096906 Carbonic anhydrases; II & IX SELECTIVITY GROUP
CHEMBL2095180 Carbonic anhydrase PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1743027 GIRENTUXIMAB Carbonic anhydrase IX other 3 Other PubMed
CHEMBL2108713 IODINE I 124 GIRENTUXIMAB Carbonic anhydrase IX binding agent 0 PubMed
CHEMBL3707280 CG250 111IN Carbonic anhydrase IX binding agent 0
CHEMBL3707297 CG250 177LU Carbonic anhydrase IX binding agent 0 PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000107159
Ensembl ENSG00000107159
GO Cellular Component GO:0005634 (nucleus)
GO:0005730 (nucleolus)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016323 (basolateral plasma membrane)
GO:0031528 (microvillus membrane)
GO:0042995 (cell projection)
GO Molecular Function GO:0004089 (carbonate dehydratase activity)
GO:0008270 (zinc ion binding)
GO:0016829 (lyase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0001666 (response to hypoxia)
GO:0002009 (morphogenesis of an epithelium)
GO:0006730 (one-carbon metabolic process)
GO:0015701 (bicarbonate transport)
GO:0033574 (response to testosterone)
GO:0042493 (response to drug)
GO:0046903 (secretion)
GO:0061418 (regulation of transcription from RNA polymerase II promoter in response to hypoxia)
Wikipedia Carbonic_anhydrase_9

Target Cross References - Protein

canSAR Q16790
Human Protein Atlas ENSG00000107159
IntAct Q16790
MICAD NBK43528 (Carbonic anhydrase IX)
Open Targets ENSG00000107159
PharmGKB PA25998
Reactome R-HSA-1234158 (Regulation of gene expression by Hypoxia-inducible Factor.)
R-HSA-1475029 (Reversible hydration of carbon dioxide.)
UniProt Q16790 Q5T4R1

Target Cross References - Domain

InterPro IPR001148 (Carbonic_anhydrase_a.)
IPR018338 (Carbonic_anhydrase_a-class_CS.)
IPR018429 (CA9.)
IPR023561 (Carbonic_anhydrase_a-class.)
Pfam PF00194 (Carb_anhydrase)

Target Cross References - Structure

PDBe 2HKF 3IAI 5DVX 5FL4 5FL5 5FL6
CREDO 2HKF 3IAI 5DVX 5FL4 5FL5 5FL6
spacer
spacer