ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL3593
Target Type SINGLE PROTEIN
Preferred Name Lanosterol synthase
Synonyms 2,3-epoxysqualene--lanosterol cyclase | LSS | Lanosterol synthase | OSC | OSC | Oxidosqualene--lanosterol cyclase | hOSC
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Lanosterol synthase SINGLE PROTEIN P48449

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000160285
Ensembl ENSG00000160285
GO Cellular Component GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005811 (lipid particle)
GO:0016020 (membrane)
GO Molecular Function GO:0000250 (lanosterol synthase activity)
GO:0016853 (isomerase activity)
GO:0016866 (intramolecular transferase activity)
GO Biological Process GO:0006629 (lipid metabolic process)
GO:0006694 (steroid biosynthetic process)
GO:0006695 (cholesterol biosynthetic process)
GO:0031647 (regulation of protein stability)
Wikipedia Lanosterol_synthase

Target Cross References - Protein

canSAR P48449
Human Protein Atlas ENSG00000160285
IntAct P48449
Guide to Pharmacology 2434
Open Targets ENSG00000160285
PharmGKB PA30473
Reactome R-HSA-191273 (Cholesterol biosynthesis.)
R-HSA-2426168 (Activation of gene expression by SREBF (SREBP).)
UniProt B4DJZ9 D3DSN0 E9PEI9 G5E9Q9 P48449 Q8IYL6 Q9UEZ1

Target Cross References - Domain

InterPro IPR002365 (Terpene_synthase_CS.)
IPR008930 (Terpenoid_cyclase/PrenylTrfase.)
IPR018333 (Squalene_cyclase.)
IPR032696 (SQ_cyclase_C.)
IPR032697 (SQ_cyclase_N.)
Pfam PF13243 (SQHop_cyclase_C)
PF13249 (SQHop_cyclase_N)

Target Cross References - Structure

PDBe 1W6J 1W6K
CREDO 1W6J 1W6K
spacer
spacer