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Target Report Card

Target Name and Classification

Target ID CHEMBL3592
Target Type SINGLE PROTEIN
Preferred Name Squalene monooxygenase
Synonyms ERG1 | SE | SQLE | Squalene epoxidase | Squalene monooxygenase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Squalene monooxygenase SINGLE PROTEIN Q14534

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000104549
Ensembl ENSG00000104549
GO Cellular Component GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0031090 (organelle membrane)
GO:0043231 (intracellular membrane-bounded organelle)
GO Molecular Function GO:0004506 (squalene monooxygenase activity)
GO:0016491 (oxidoreductase activity)
GO:0050660 (flavin adenine dinucleotide binding)
GO Biological Process GO:0006695 (cholesterol biosynthetic process)
GO:0006725 (cellular aromatic compound metabolic process)
GO:0008203 (cholesterol metabolic process)
GO:0010033 (response to organic substance)
GO:0016126 (sterol biosynthetic process)
GO:0055114 (oxidation-reduction process)
Wikipedia Squalene_monooxygenase

Target Cross References - Protein

Human Protein Atlas ENSG00000104549
IntAct Q14534
Guide to Pharmacology 2433
Open Targets ENSG00000104549
PharmGKB PA36108
Reactome R-HSA-191273 (Cholesterol biosynthesis.)
R-HSA-2426168 (Activation of gene expression by SREBF (SREBP).)
UniProt Q14534 Q9UEK6

Target Cross References - Domain

InterPro IPR013698 (Squalene_epoxidase.)
IPR023753 (FAD/NAD-binding_dom.)
Pfam PF08491 (SE)
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