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Target Report Card

Target Name and Classification

Target ID CHEMBL3590
Preferred Name Hormone sensitive lipase
Synonyms HSL | Hormone-sensitive lipase | LIPE
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Hormone-sensitive lipase SINGLE PROTEIN Q05469

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000079435
Ensembl ENSG00000079435
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005811 (lipid particle)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005901 (caveola)
GO:0016020 (membrane)
GO Molecular Function GO:0004806 (triglyceride lipase activity)
GO:0005515 (protein binding)
GO:0016298 (lipase activity)
GO:0016787 (hydrolase activity)
GO:0019901 (protein kinase binding)
GO:0033878 (hormone-sensitive lipase activity)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0006629 (lipid metabolic process)
GO:0008152 (metabolic process)
GO:0008202 (steroid metabolic process)
GO:0008203 (cholesterol metabolic process)
GO:0016042 (lipid catabolic process)
GO:0019433 (triglyceride catabolic process)
GO:0042758 (long-chain fatty acid catabolic process)
GO:0046340 (diacylglycerol catabolic process)
Wikipedia Hormone-sensitive_lipase

Target Cross References - Protein

canSAR Q05469
Human Protein Atlas ENSG00000079435
IntAct Q05469
Guide to Pharmacology 2593
Open Targets ENSG00000079435
PharmGKB PA30393
Reactome R-HSA-163560 (Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis.)
UniProt Q05469 Q3LRT2 Q6NSL7

Target Cross References - Domain

InterPro IPR002168 (Lipase_GDXG_HIS_AS.)
IPR010468 (HSL_N.)
IPR013094 (AB_hydrolase_3.)
IPR029058 (AB_hydrolase.)
IPR033140 (Lipase_GDXG_put_SER_AS.)
Pfam PF06350 (HSL_N)
PF07859 (Abhydrolase_3)