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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3582
Target Type SINGLE PROTEIN
Preferred Name Protein kinase C epsilon
Synonyms PKCE | PRKCE | Protein kinase C epsilon type | nPKC-epsilon
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > agc protein kinase group > agc protein kinase pkc family > agc protein kinase pkc eta subfamily

Target Components

Component Description Relationship Accession
Protein kinase C epsilon type SINGLE PROTEIN Q02156

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2096620 Protein kinase C, PKC; classical/novel PROTEIN FAMILY
CHEMBL2093867 Protein kinase C (PKC) PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000171132
Ensembl ENSG00000171132
GO Cellular Component GO:0005783 (endoplasmic reticulum)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0005524 (ATP binding)
GO:0008047 (enzyme activator activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0006917 (induction of apoptosis)
GO:0007202 (activation of phospholipase C activity)
GO:0030168 (platelet activation)
GO:0035556 (intracellular signal transduction)
GO:0048011 (nerve growth factor receptor signaling pathway)
Wikipedia PRKCE

Target Cross References - Protein

canSAR Q02156
Human Protein Atlas ENSG00000171132
IntAct Q02156
Guide to Pharmacology 1486 (protein kinase C, epsilon)
PharmGKB PA33765
Reactome REACT_11061 (Signalling by NGF.)
REACT_14797 (Signaling by GPCR.)
REACT_604 (Hemostasis.)
UniProt B0LPH7 Q02156 Q32MQ3 Q53SL4 Q53SM5 Q9UE81

Target Cross References - Domain

InterPro IPR000008 (C2_Ca-dep.)
IPR000719 (Prot_kinase_cat_dom.)
IPR000961 (AGC-kinase_C.)
IPR002219 (Prot_Kinase_C-like_PE/DAG-bd.)
IPR002290 (Ser/Thr_prot_kinase_dom.)
IPR008271 (Ser/Thr_prot_kinase_AS.)
IPR008973 (C2_Ca/lipid-bd_dom_CaLB.)
IPR011009 (Kinase-like_dom.)
IPR014376 (Prot_kin_PKC_delta.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR017442 (Se/Thr_prot_kinase-like_dom.)
IPR017892 (Pkinase_C.)
IPR018029 (C2_membr_targeting.)
IPR020454 (DAG/PE-bd.)
Pfam PF00069 (Pkinase)
PF00130 (C1_1)
PF00168 (C2)
PF00433 (Pkinase_C)

Target Cross References - Structure

PDBe 2WH0
CREDO 2WH0
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