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Target Report Card

Target Name and Classification

Target ID CHEMBL3582
Target Type SINGLE PROTEIN
Preferred Name Protein kinase C epsilon
Synonyms PKCE | PRKCE | Protein kinase C epsilon type | nPKC-epsilon
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > agc protein kinase group > agc protein kinase pkc family > agc protein kinase pkc eta subfamily

Target Components

Component Description Relationship Accession
Protein kinase C epsilon type SINGLE PROTEIN Q02156

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2093867 Protein kinase C (PKC) PROTEIN FAMILY
CHEMBL2096620 Protein kinase C, PKC; classical/novel PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000171132
Ensembl ENSG00000171132
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005783 (endoplasmic reticulum)
GO:0005794 (Golgi apparatus)
GO:0005829 (cytosol)
GO:0005856 (cytoskeleton)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0048471 (perinuclear region of cytoplasm)
GO:0071944 (cell periphery)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0003785 (actin monomer binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004697 (protein kinase C activity)
GO:0004699 (calcium-independent protein kinase C activity)
GO:0004871 (signal transducer activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0008047 (enzyme activator activity)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0019899 (enzyme binding)
GO:0030546 (receptor activator activity)
GO:0035276 (ethanol binding)
GO:0046872 (metal ion binding)
GO:0071889 (14-3-3 protein binding)
GO Biological Process GO:0002281 (macrophage activation involved in immune response)
GO:0002376 (immune system process)
GO:0006468 (protein phosphorylation)
GO:0006915 (apoptotic process)
GO:0007049 (cell cycle)
GO:0007155 (cell adhesion)
GO:0007165 (signal transduction)
GO:0007202 (activation of phospholipase C activity)
GO:0010634 (positive regulation of epithelial cell migration)
GO:0010763 (positive regulation of fibroblast migration)
GO:0010811 (positive regulation of cell-substrate adhesion)
GO:0016310 (phosphorylation)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0019216 (regulation of lipid metabolic process)
GO:0030168 (platelet activation)
GO:0030838 (positive regulation of actin filament polymerization)
GO:0031397 (negative regulation of protein ubiquitination)
GO:0031663 (lipopolysaccharide-mediated signaling pathway)
GO:0032024 (positive regulation of insulin secretion)
GO:0032230 (positive regulation of synaptic transmission, GABAergic)
GO:0032467 (positive regulation of cytokinesis)
GO:0035556 (intracellular signal transduction)
GO:0035641 (locomotory exploration behavior)
GO:0035669 (TRAM-dependent toll-like receptor 4 signaling pathway)
GO:0038096 (Fc-gamma receptor signaling pathway involved in phagocytosis)
GO:0043123 (positive regulation of I-kappaB kinase/NF-kappaB signaling)
GO:0043278 (response to morphine)
GO:0043410 (positive regulation of MAPK cascade)
GO:0050730 (regulation of peptidyl-tyrosine phosphorylation)
GO:0050996 (positive regulation of lipid catabolic process)
GO:0051209 (release of sequestered calcium ion into cytosol)
GO:0051279 (regulation of release of sequestered calcium ion into cytosol)
GO:0051301 (cell division)
GO:0061178 (regulation of insulin secretion involved in cellular response to glucose stimulus)
GO:0070257 (positive regulation of mucus secretion)
GO:0071361 (cellular response to ethanol)
GO:0071380 (cellular response to prostaglandin E stimulus)
GO:0071456 (cellular response to hypoxia)
GO:0090303 (positive regulation of wound healing)
GO:2000273 (positive regulation of receptor activity)
GO:2000650 (negative regulation of sodium ion transmembrane transporter activity)
GO:2001031 (positive regulation of cellular glucuronidation)
Wikipedia PRKCE

Target Cross References - Protein

canSAR Q02156
Human Protein Atlas ENSG00000171132
IntAct Q02156
Guide to Pharmacology 1486
Open Targets ENSG00000171132
PharmGKB PA33765
Pharos Q02156 (Tchem)
Reactome R-HSA-114508 (Effects of PIP2 hydrolysis.)
R-HSA-1250196 (SHC1 events in ERBB2 signaling.)
R-HSA-1489509 (DAG and IP3 signaling.)
R-HSA-2029485 (Role of phospholipids in phagocytosis.)
R-HSA-418597 (G alpha (z) signalling events.)
UniProt B0LPH7 Q02156 Q32MQ3 Q53SL4 Q53SM5 Q9UE81

Target Cross References - Domain

InterPro IPR000008 (C2_dom.)
IPR000719 (Prot_kinase_dom.)
IPR000961 (AGC-kinase_C.)
IPR002219 (PE/DAG-bd.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR014376 (Prot_kin_PKC_delta.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR017892 (Pkinase_C.)
IPR020454 (DAG/PE-bd.)
IPR027274 (PKC_epsilon.)
Pfam PF00069 (Pkinase)
PF00130 (C1_1)
PF00168 (C2)
PF00433 (Pkinase_C)

Target Cross References - Structure

PDBe 2WH0 5LIH
CREDO 2WH0 5LIH
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