ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL3579
Target Type SINGLE PROTEIN
Preferred Name Aldehyde dehydrogenase 1A3
Synonyms ALDH1A3 | ALDH6 | Aldehyde dehydrogenase 6 | Aldehyde dehydrogenase family 1 member A3 | RALDH-3 | RalDH3 | Retinaldehyde dehydrogenase 3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Aldehyde dehydrogenase family 1 member A3 SINGLE PROTEIN P47895

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3542434 Aldehyde dehydrogenase PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000184254
Ensembl ENSG00000184254
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0001758 (retinal dehydrogenase activity)
GO:0004029 (aldehyde dehydrogenase (NAD) activity)
GO:0004030 (aldehyde dehydrogenase [NAD(P)+] activity)
GO:0016491 (oxidoreductase activity)
GO:0016620 (oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor)
GO:0042803 (protein homodimerization activity)
GO:0070324 (thyroid hormone binding)
GO:0070403 (NAD+ binding)
GO Biological Process GO:0002072 (optic cup morphogenesis involved in camera-type eye development)
GO:0002138 (retinoic acid biosynthetic process)
GO:0007626 (locomotory behavior)
GO:0008152 (metabolic process)
GO:0021768 (nucleus accumbens development)
GO:0031076 (embryonic camera-type eye development)
GO:0042472 (inner ear morphogenesis)
GO:0042572 (retinol metabolic process)
GO:0042573 (retinoic acid metabolic process)
GO:0042574 (retinal metabolic process)
GO:0043065 (positive regulation of apoptotic process)
GO:0048048 (embryonic eye morphogenesis)
GO:0050885 (neuromuscular process controlling balance)
GO:0055114 (oxidation-reduction process)
GO:0060013 (righting reflex)
GO:0060166 (olfactory pit development)
GO:0060324 (face development)
Wikipedia ALDH1A3

Target Cross References - Protein

canSAR P47895
CGD Microphthalmia, isolated 8
Human Protein Atlas ENSG00000184254
Open Targets ENSG00000184254
PharmGKB PA24694
Reactome R-HSA-5365859 (RA biosynthesis pathway.)
UniProt P47895 Q6NT64

Target Cross References - Domain

InterPro IPR015590 (Aldehyde_DH_dom.)
IPR016160 (Ald_DH_CS_CYS.)
IPR016161 (Ald_DH/histidinol_DH.)
IPR016162 (Ald_DH_N.)
IPR016163 (Ald_DH_C.)
IPR029510 (Ald_DH_CS_GLU.)
Pfam PF00171 (Aldedh)

Target Cross References - Structure

PDBe 5FHZ
CREDO 5FHZ
spacer
spacer