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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3578
Target Type SINGLE PROTEIN
Preferred Name Aldehyde dehydrogenase dimeric NADP-preferring
Synonyms ALDH3 | ALDH3A1 | ALDHIII | Aldehyde dehydrogenase 3 | Aldehyde dehydrogenase family 3 member A1 | Aldehyde dehydrogenase, dimeric NADP-preferring
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Aldehyde dehydrogenase, dimeric NADP-preferring SINGLE PROTEIN P30838

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3542434 Aldehyde dehydrogenase PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000108602
Ensembl ENSG00000108602
GO Cellular Component GO:0005615 (extracellular space)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005783 (endoplasmic reticulum)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0016021 (integral component of membrane)
GO:0043231 (intracellular membrane-bounded organelle)
GO Molecular Function GO:0004028 (3-chloroallyl aldehyde dehydrogenase activity)
GO:0004029 (aldehyde dehydrogenase (NAD) activity)
GO:0004030 (aldehyde dehydrogenase [NAD(P)+] activity)
GO:0005515 (protein binding)
GO:0008106 (alcohol dehydrogenase (NADP+) activity)
GO:0016491 (oxidoreductase activity)
GO:0016620 (oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor)
GO:0018479 (benzaldehyde dehydrogenase (NAD+) activity)
GO Biological Process GO:0001666 (response to hypoxia)
GO:0006081 (cellular aldehyde metabolic process)
GO:0006805 (xenobiotic metabolic process)
GO:0007568 (aging)
GO:0007584 (response to nutrient)
GO:0008152 (metabolic process)
GO:0008284 (positive regulation of cell proliferation)
GO:0014070 (response to organic cyclic compound)
GO:0042493 (response to drug)
GO:0051384 (response to glucocorticoid)
GO:0051591 (response to cAMP)
GO:0055114 (oxidation-reduction process)
Wikipedia Aldehyde_dehydrogenase_3_family,_member_A1

Target Cross References - Protein

Human Protein Atlas ENSG00000108602
IntAct P30838
Open Targets ENSG00000108602
PharmGKB PA24697
Reactome R-HSA-211945 (Phase 1 - Functionalization of compounds.)
UniProt A8K828 P30838 Q9BT37

Target Cross References - Domain

InterPro IPR012394 (Aldehyde_DH_NAD(P).)
IPR015590 (Aldehyde_DH_dom.)
IPR016160 (Ald_DH_CS_CYS.)
IPR016161 (Ald_DH/histidinol_DH.)
IPR016162 (Ald_DH_N.)
IPR016163 (Ald_DH_C.)
IPR029510 (Ald_DH_CS_GLU.)
Pfam PF00171 (Aldedh)

Target Cross References - Structure

PDBe 3SZA 3SZB 4H80 4L1O 4L2O
CREDO 3SZA 3SZB 4H80 4L1O 4L2O
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