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Target Report Card

Target Name and Classification

Target ID CHEMBL3577
Preferred Name Aldehyde dehydrogenase 1A1
Synonyms ALDH-E1 | ALDH1 | ALDH1A1 | ALHDII | Aldehyde dehydrogenase family 1 member A1 | Aldehyde dehydrogenase, cytosolic | PUMB1 | RALDH 1 | RalDH1 | Retinal dehydrogenase 1 | Synonyms=ALDC
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Retinal dehydrogenase 1 SINGLE PROTEIN P00352

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3542434 Aldehyde dehydrogenase PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000165092
Ensembl ENSG00000165092
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0001758 (retinal dehydrogenase activity)
GO:0004029 (aldehyde dehydrogenase (NAD) activity)
GO:0005096 (GTPase activator activity)
GO:0005497 (androgen binding)
GO:0016491 (oxidoreductase activity)
GO:0016620 (oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor)
GO:0018479 (benzaldehyde dehydrogenase (NAD+) activity)
GO:0051287 (NAD binding)
GO Biological Process GO:0001523 (retinoid metabolic process)
GO:0006069 (ethanol oxidation)
GO:0006081 (cellular aldehyde metabolic process)
GO:0008152 (metabolic process)
GO:0042572 (retinol metabolic process)
GO:0043547 (positive regulation of GTPase activity)
GO:0055114 (oxidation-reduction process)
GO:0061624 (fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate)
Wikipedia ALDH1A1

Target Cross References - Protein

canSAR P00352
Human Protein Atlas ENSG00000165092
IntAct P00352
Open Targets ENSG00000165092
PharmGKB PA24692
Reactome R-HSA-5365859 (RA biosynthesis pathway.)
R-HSA-70350 (Fructose catabolism.)
R-HSA-71384 (Ethanol oxidation.)
UniProt O00768 P00352 Q5SYR1

Target Cross References - Domain

InterPro IPR015590 (Aldehyde_DH_dom.)
IPR016160 (Ald_DH_CS_CYS.)
IPR016161 (Ald_DH/histidinol_DH.)
IPR016162 (Ald_DH_N.)
IPR016163 (Ald_DH_C.)
IPR029510 (Ald_DH_CS_GLU.)
Pfam PF00171 (Aldedh)

Target Cross References - Structure

PDBe 4WB9 4WJ9 4WP7 4WPN 4X4L 5AC2 5L2M 5L2N 5L2O 5TEI
CREDO 4WB9 4WJ9 4WP7 4WPN 4X4L 5AC2 5L2M 5L2N 5L2O 5TEI