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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3575
Target Type SINGLE PROTEIN
Preferred Name RNase L
Synonyms 2-5A-dependent RNase | 2-5A-dependent ribonuclease | RNASEL | RNS4 | RNase L | Ribonuclease 4 | Ribonuclease L
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > hydrolase

Target Components

Component Description Relationship Accession
2-5A-dependent ribonuclease SINGLE PROTEIN Q05823

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000135828
Ensembl ENSG00000135828
GO Cellular Component GO:0005575 (cellular_component)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005759 (mitochondrial matrix)
GO:0005829 (cytosol)
GO:0016363 (nuclear matrix)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0003723 (RNA binding)
GO:0004518 (nuclease activity)
GO:0004519 (endonuclease activity)
GO:0004521 (endoribonuclease activity)
GO:0004540 (ribonuclease activity)
GO:0004672 (protein kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016787 (hydrolase activity)
GO:0019843 (rRNA binding)
GO:0043021 (ribonucleoprotein complex binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006364 (rRNA processing)
GO:0006397 (mRNA processing)
GO:0006468 (protein phosphorylation)
GO:0043488 (regulation of mRNA stability)
GO:0045071 (negative regulation of viral genome replication)
GO:0045444 (fat cell differentiation)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0051607 (defense response to virus)
GO:0055085 (transmembrane transport)
GO:0060337 (type I interferon signaling pathway)
GO:0090501 (RNA phosphodiester bond hydrolysis)
GO:0090502 (RNA phosphodiester bond hydrolysis, endonucleolytic)
GO:2001275 (positive regulation of glucose import in response to insulin stimulus)
Wikipedia RNASEL

Target Cross References - Protein

canSAR Q05823
CGD Prostate cancer, hereditary, 1
Human Protein Atlas ENSG00000135828
IntAct Q05823
Open Targets ENSG00000135828
PharmGKB PA34418
Pharos Q05823 (Tchem)
Reactome R-HSA-382556 (ABC-family proteins mediated transport.)
R-HSA-909733 (Interferon alpha/beta signaling.)
UniProt Q05823 Q5W0L2 Q6AI46

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR002110 (Ankyrin_rpt.)
IPR010513 (KEN_dom.)
IPR011009 (Kinase-like_dom.)
IPR018997 (PUB_domain.)
IPR020683 (Ankyrin_rpt-contain_dom.)
Pfam PF00069 (Pkinase)
PF06479 (Ribonuc_2-5A)
PF12796 (Ank_2)

Target Cross References - Structure

PDBe 1WDY 4G8K 4G8L 4OAU 4OAV
CREDO 1WDY 4G8K 4G8L 4OAU 4OAV
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