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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3572
Target Type SINGLE PROTEIN
Preferred Name Cholesteryl ester transfer protein
Synonyms CETP | Cholesteryl ester transfer protein | Lipid transfer protein I
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > other ion channel > pore-forming toxins (proteins and peptides)

Target Components

Component Description Relationship Accession
Cholesteryl ester transfer protein SINGLE PROTEIN P11597

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL313006 DALCETRAPIB Cholesteryl ester transfer protein inhibitor 3 PubMed PubMed
CHEMBL1800807 ANACETRAPIB Cholesteryl ester transfer protein inhibitor 3 PubMed
CHEMBL2017179 EVACETRAPIB Cholesteryl ester transfer protein inhibitor 3 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000087237
Ensembl ENSG00000087237
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0031982 (vesicle)
GO:0034364 (high-density lipoprotein particle)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0005319 (lipid transporter activity)
GO:0005548 (phospholipid transporter activity)
GO:0008289 (lipid binding)
GO:0015485 (cholesterol binding)
GO:0017127 (cholesterol transporter activity)
GO:0017129 (triglyceride binding)
GO:0031210 (phosphatidylcholine binding)
GO Biological Process GO:0006629 (lipid metabolic process)
GO:0006641 (triglyceride metabolic process)
GO:0006810 (transport)
GO:0006869 (lipid transport)
GO:0006898 (receptor-mediated endocytosis)
GO:0008202 (steroid metabolic process)
GO:0008203 (cholesterol metabolic process)
GO:0010745 (negative regulation of macrophage derived foam cell differentiation)
GO:0010874 (regulation of cholesterol efflux)
GO:0015914 (phospholipid transport)
GO:0030301 (cholesterol transport)
GO:0034197 (triglyceride transport)
GO:0034372 (very-low-density lipoprotein particle remodeling)
GO:0034374 (low-density lipoprotein particle remodeling)
GO:0034375 (high-density lipoprotein particle remodeling)
GO:0042157 (lipoprotein metabolic process)
GO:0042632 (cholesterol homeostasis)
GO:0043691 (reverse cholesterol transport)
GO:0046470 (phosphatidylcholine metabolic process)
GO:0055088 (lipid homeostasis)
GO:0055091 (phospholipid homeostasis)
GO:0070328 (triglyceride homeostasis)
Wikipedia Cholesterylester_transfer_protein

Target Cross References - Protein

canSAR P11597
CGD Hyperalphalipoproteinemia 1
Human Protein Atlas ENSG00000087237
IntAct P11597
Open Targets ENSG00000087237
PharmGKB PA108
Reactome R-HSA-171052 (LDL-mediated lipid transport.)
R-HSA-194223 (HDL-mediated lipid transport.)
UniProt P11597 Q13987 Q13988 Q53YZ1

Target Cross References - Domain

InterPro IPR001124 (Lipid-bd_serum_glycop_C.)
IPR017130 (Cholesteryl_ester_transfer.)
IPR017942 (Lipid-bd_serum_glycop_N.)
IPR017943 (Bactericidal_perm-incr_a/b_dom.)
IPR017954 (Lipid-bd_serum_glycop_CS.)
IPR032942 (BPI/LBP/Plunc.)
Pfam PF01273 (LBP_BPI_CETP)
PF02886 (LBP_BPI_CETP_C)

Target Cross References - Structure

PDBe 2OBD 4EWS 4F2A
CREDO 2OBD 4EWS 4F2A
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