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Target Report Card

Target Name and Classification

Target ID CHEMBL3568
Target Type SINGLE PROTEIN
Preferred Name Nitric-oxide synthase, brain
Synonyms Constitutive NOS | N-NOS | NC-NOS | NOS type I | NOS1 | Neuronal NOS | Nitric oxide synthase, brain | Peptidyl-cysteine S-nitrosylase NOS1 | bNOS | nNOS
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Nitric oxide synthase, brain SINGLE PROTEIN P29475

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111405 Nitric-oxide synthase (endothelial and brain) SELECTIVITY GROUP
CHEMBL2096621 Nitric oxide sythases; iNOS & nNOS SELECTIVITY GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000089250
Ensembl ENSG00000089250
GO Cellular Component GO:0001917 (photoreceptor inner segment)
GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005741 (mitochondrial outer membrane)
GO:0005829 (cytosol)
GO:0005856 (cytoskeleton)
GO:0005886 (plasma membrane)
GO:0005901 (caveola)
GO:0012506 (vesicle membrane)
GO:0014069 (postsynaptic density)
GO:0016020 (membrane)
GO:0016529 (sarcoplasmic reticulum)
GO:0030018 (Z disc)
GO:0030315 (T-tubule)
GO:0030425 (dendrite)
GO:0031965 (nuclear membrane)
GO:0033017 (sarcoplasmic reticulum membrane)
GO:0042383 (sarcolemma)
GO:0042582 (azurophil granule)
GO:0042995 (cell projection)
GO:0043197 (dendritic spine)
GO:0043234 (protein complex)
GO:0045121 (membrane raft)
GO:0045202 (synapse)
GO:0048471 (perinuclear region of cytoplasm)
GO:1990425 (ryanodine receptor complex)
GO Molecular Function GO:0004517 (nitric-oxide synthase activity)
GO:0005506 (iron ion binding)
GO:0005515 (protein binding)
GO:0005516 (calmodulin binding)
GO:0010181 (FMN binding)
GO:0016491 (oxidoreductase activity)
GO:0017080 (sodium channel regulator activity)
GO:0019899 (enzyme binding)
GO:0020037 (heme binding)
GO:0034617 (tetrahydrobiopterin binding)
GO:0034618 (arginine binding)
GO:0042803 (protein homodimerization activity)
GO:0044325 (ion channel binding)
GO:0046870 (cadmium ion binding)
GO:0046872 (metal ion binding)
GO:0050660 (flavin adenine dinucleotide binding)
GO:0050661 (NADP binding)
GO:0097110 (scaffold protein binding)
GO Biological Process GO:0001666 (response to hypoxia)
GO:0002028 (regulation of sodium ion transport)
GO:0006527 (arginine catabolic process)
GO:0006809 (nitric oxide biosynthetic process)
GO:0006941 (striated muscle contraction)
GO:0007263 (nitric oxide mediated signal transduction)
GO:0007520 (myoblast fusion)
GO:0007565 (female pregnancy)
GO:0007568 (aging)
GO:0008016 (regulation of heart contraction)
GO:0008285 (negative regulation of cell proliferation)
GO:0009408 (response to heat)
GO:0010243 (response to organonitrogen compound)
GO:0010288 (response to lead ion)
GO:0010523 (negative regulation of calcium ion transport into cytosol)
GO:0014070 (response to organic cyclic compound)
GO:0014823 (response to activity)
GO:0018119 (peptidyl-cysteine S-nitrosylation)
GO:0031284 (positive regulation of guanylate cyclase activity)
GO:0031667 (response to nutrient levels)
GO:0032496 (response to lipopolysaccharide)
GO:0033197 (response to vitamin E)
GO:0033555 (multicellular organismal response to stress)
GO:0035066 (positive regulation of histone acetylation)
GO:0035094 (response to nicotine)
GO:0042136 (neurotransmitter biosynthetic process)
GO:0042738 (exogenous drug catabolic process)
GO:0043066 (negative regulation of apoptotic process)
GO:0043267 (negative regulation of potassium ion transport)
GO:0043434 (response to peptide hormone)
GO:0043627 (response to estrogen)
GO:0045454 (cell redox homeostasis)
GO:0045471 (response to ethanol)
GO:0045776 (negative regulation of blood pressure)
GO:0045822 (negative regulation of heart contraction)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0045906 (negative regulation of vasoconstriction)
GO:0045909 (positive regulation of vasodilation)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0046676 (negative regulation of insulin secretion)
GO:0048148 (behavioral response to cocaine)
GO:0050767 (regulation of neurogenesis)
GO:0051346 (negative regulation of hydrolase activity)
GO:0051481 (negative regulation of cytosolic calcium ion concentration)
GO:0051612 (negative regulation of serotonin uptake)
GO:0051926 (negative regulation of calcium ion transport)
GO:0051930 (regulation of sensory perception of pain)
GO:0055114 (oxidation-reduction process)
GO:0055117 (regulation of cardiac muscle contraction)
GO:0060314 (regulation of ryanodine-sensitive calcium-release channel activity)
GO:0071260 (cellular response to mechanical stimulus)
GO:0071363 (cellular response to growth factor stimulus)
GO:0071731 (response to nitric oxide)
GO:0098735 (positive regulation of the force of heart contraction)
GO:1900273 (positive regulation of long-term synaptic potentiation)
GO:1901205 (negative regulation of adrenergic receptor signaling pathway involved in heart process)
GO:1901206 (positive regulation of adrenergic receptor signaling pathway involved in heart process)
GO:1901216 (positive regulation of neuron death)
GO:1902307 (positive regulation of sodium ion transmembrane transport)
GO:1902514 (regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)
GO:1903779 (regulation of cardiac conduction)
Wikipedia NOS1

Target Cross References - Protein

canSAR P29475
Human Protein Atlas ENSG00000089250
IntAct P29475
Guide to Pharmacology 1251
Open Targets ENSG00000089250
PharmGKB PA252
Reactome R-HSA-1222556 (ROS, RNS production in phagocytes.)
R-HSA-392154 (Nitric oxide stimulates guanylate cyclase.)
R-HSA-5578775 (Ion homeostasis.)
UniProt E9PH30 O75713 P29475

Target Cross References - Domain

InterPro IPR001094 (Flavdoxin-like.)
IPR001433 (OxRdtase_FAD/NAD-bd.)
IPR001478 (PDZ.)
IPR001709 (Flavoprot_Pyr_Nucl_cyt_Rdtase.)
IPR003097 (FAD-binding_1.)
IPR004030 (NOS_N.)
IPR008254 (Flavodoxin/NO_synth.)
IPR012144 (NOS_euk.)
IPR017927 (Fd_Rdtase_FAD-bd.)
IPR017938 (Riboflavin_synthase-like_b-brl.)
IPR023173 (NADPH_Cyt_P450_Rdtase_dom3.)
IPR029039 (Flavoprotein-like_dom.)
Pfam PF00175 (NAD_binding_1)
PF00258 (Flavodoxin_1)
PF00595 (PDZ)
PF00667 (FAD_binding_1)
PF02898 (NO_synthase)

Target Cross References - Structure

PDBe 4D1N 4UCH 4UH5 4UH6 4V3U 5ADF 5ADG 5ADI 5FVU 5FVV 5FVW 5FVX
CREDO 4D1N 4UCH 4UH5 4UH6 4V3U 5ADF 5ADG 5ADI 5FVU 5FVV 5FVW 5FVX
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