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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3561
Target Type SINGLE PROTEIN
Preferred Name GABA receptor rho-1 subunit
Synonyms GABA(A) receptor subunit rho-1 | GABA(C) receptor | GABRR1 | Gamma-aminobutyric acid receptor subunit rho-1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > ligand-gated ion channel > gaba-a receptor

Target Components

Component Description Relationship Accession
Gamma-aminobutyric acid receptor subunit rho-1 SINGLE PROTEIN P24046

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2109242 GABA-C receptor PROTEIN COMPLEX GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000146276
Ensembl ENSG00000146276
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030054 (cell junction)
GO:0034707 (chloride channel complex)
GO:0045202 (synapse)
GO:0045211 (postsynaptic membrane)
GO:1902711 (GABA-A receptor complex)
GO Molecular Function GO:0004890 (GABA-A receptor activity)
GO:0005230 (extracellular ligand-gated ion channel activity)
GO:0005254 (chloride channel activity)
GO:0016917 (GABA receptor activity)
GO:0019904 (protein domain specific binding)
GO:0042803 (protein homodimerization activity)
GO:0046982 (protein heterodimerization activity)
GO Biological Process GO:0006810 (transport)
GO:0006811 (ion transport)
GO:0006821 (chloride transport)
GO:0007165 (signal transduction)
GO:0007214 (gamma-aminobutyric acid signaling pathway)
GO:0007268 (chemical synaptic transmission)
GO:0034220 (ion transmembrane transport)
GO:1902476 (chloride transmembrane transport)
Wikipedia GABRR1

Target Cross References - Protein

canSAR P24046
Human Protein Atlas ENSG00000146276
IntAct P24046
Open Targets ENSG00000146276
PharmGKB PA28505
Pharos P24046 (Tchem)
Reactome R-HSA-975298 (Ligand-gated ion channel transport.)
R-HSA-977442 (GABA A (rho) receptor activation.)
UniProt A1L401 B4DJK8 B4DQT5 B7ZBQ7 P24046 Q9BX06

Target Cross References - Domain

InterPro IPR006028 (GABAA/Glycine_rcpt.)
IPR006029 (Neurotrans-gated_channel_TM.)
IPR006201 (Neur_channel.)
IPR006202 (Neur_chan_lig-bd.)
IPR008057 (GABAAa_rho_rcpt.)
IPR008058 (GABAAa_rho1_rcpt.)
IPR018000 (Neurotransmitter_ion_chnl_CS.)
Pfam PF02931 (Neur_chan_LBD)
PF02932 (Neur_chan_memb)
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