ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL3553
Target Type SINGLE PROTEIN
Preferred Name Tyrosine-protein kinase TYK2
Synonyms Non-receptor tyrosine-protein kinase TYK2 | TYK2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase jakb family
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase jaka family

Target Components

Component Description Relationship Accession
Non-receptor tyrosine-protein kinase TYK2 SINGLE PROTEIN P29597

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3301391 JAK1/TYK2 PROTEIN COMPLEX
CHEMBL3301390 JAK1/JAK2/TYK2 PROTEIN COMPLEX
CHEMBL3301392 JAK2/TYK2 PROTEIN COMPLEX
CHEMBL2363062 Janus Kinase (JAK) PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL3545284 Cerdulatinib Tyrosine-protein kinase TYK2 inhibitor 2 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000105397
Ensembl ENSG00000105397
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005856 (cytoskeleton)
GO:0016020 (membrane)
GO:0031234 (extrinsic component of cytoplasmic side of plasma membrane)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0004715 (non-membrane spanning protein tyrosine kinase activity)
GO:0005131 (growth hormone receptor binding)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0031702 (type 1 angiotensin receptor binding)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway)
GO:0016310 (phosphorylation)
GO:0016477 (cell migration)
GO:0030154 (cell differentiation)
GO:0035556 (intracellular signal transduction)
GO:0038083 (peptidyl-tyrosine autophosphorylation)
GO:0042127 (regulation of cell proliferation)
GO:0045087 (innate immune response)
GO:0060337 (type I interferon signaling pathway)
GO:0060338 (regulation of type I interferon-mediated signaling pathway)
Wikipedia Tyrosine_kinase_2

Target Cross References - Protein

canSAR P29597
CGD Tyrosine kinase 2 deficiency
Human Protein Atlas ENSG00000105397
IntAct P29597
Guide to Pharmacology 2269
Open Targets ENSG00000105397
PharmGKB PA37094
Pharos P29597 (Tclin)
Reactome R-HSA-1059683 (Interleukin-6 signaling.)
R-HSA-110056 (MAPK3 (ERK1) activation.)
R-HSA-112411 (MAPK1 (ERK2) activation.)
R-HSA-6783783 (Interleukin-10 signaling.)
R-HSA-6785807 (Interleukin-4 and 13 signaling.)
R-HSA-6788467 (IL-6-type cytokine receptor ligand interactions.)
R-HSA-909733 (Interferon alpha/beta signaling.)
R-HSA-912694 (Regulation of IFNA signaling.)
UniProt P29597 Q6QB10 Q96CH0

Target Cross References - Domain

InterPro IPR000299 (FERM_domain.)
IPR000719 (Prot_kinase_dom.)
IPR000980 (SH2.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR008266 (Tyr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR011993 (PH_dom-like.)
IPR016045 (Tyr_kinase_non-rcpt_TYK2_N.)
IPR016251 (Tyr_kinase_non-rcpt_Jak/Tyk2.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR019748 (FERM_central.)
IPR019749 (Band_41_domain.)
IPR020635 (Tyr_kinase_cat_dom.)
Pfam PF07714 (Pkinase_Tyr)

Target Cross References - Structure

PDBe 3LXN 3LXP 3NYX 3NZ0 3ZON 4GFO 4GIH 4GII 4GJ2 4GJ3 4GVJ 4OLI 4PO6 4PY1 4WOV 5C01 5C03 5F1Z 5F20 5TKD
CREDO 3LXN 3LXP 3NYX 3NZ0 3ZON 4GFO 4GIH 4GII 4GJ2 4GJ3 4GVJ 4OLI 4PO6 4PY1 4WOV 5C01 5C03 5F1Z 5F20 5TKD
spacer
spacer