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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3551
Target Type SINGLE PROTEIN
Preferred Name TRAIL receptor-1
Synonyms APO2 | CD_antigen=CD261 | DR4 | Death receptor 4 | TNF-related apoptosis-inducing ligand receptor 1 | TNFRSF10A | TRAIL receptor 1 | TRAIL-R1 | TRAILR1 | Tumor necrosis factor receptor superfamily member 10A
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor

Target Components

Component Description Relationship Accession
Tumor necrosis factor receptor superfamily member 10A SINGLE PROTEIN O00220

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL2107846 DULANERMIN TRAIL receptor-1 agonist 2 PubMed PubMed
CHEMBL2108621 MAPATUMUMAB TRAIL receptor-1 agonist 2 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000104689
Ensembl ENSG00000104689
GO Cellular Component GO:0005622 (intracellular)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0002020 (protease binding)
GO:0005031 (tumor necrosis factor-activated receptor activity)
GO:0005035 (death receptor activity)
GO:0005515 (protein binding)
GO:0008134 (transcription factor binding)
GO:0038023 (signaling receptor activity)
GO:0045569 (TRAIL binding)
GO Biological Process GO:0006915 (apoptotic process)
GO:0006919 (activation of cysteine-type endopeptidase activity involved in apoptotic process)
GO:0006954 (inflammatory response)
GO:0006955 (immune response)
GO:0007165 (signal transduction)
GO:0007166 (cell surface receptor signaling pathway)
GO:0007250 (activation of NF-kappaB-inducing kinase activity)
GO:0007275 (multicellular organism development)
GO:0008625 (extrinsic apoptotic signaling pathway via death domain receptors)
GO:0032496 (response to lipopolysaccharide)
GO:0033209 (tumor necrosis factor-mediated signaling pathway)
GO:0036462 (TRAIL-activated apoptotic signaling pathway)
GO:0042127 (regulation of cell proliferation)
GO:0042981 (regulation of apoptotic process)
GO:0043154 (negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)
GO:0050900 (leukocyte migration)
GO:0071260 (cellular response to mechanical stimulus)
GO:0097191 (extrinsic apoptotic signaling pathway)
GO:0097296 (activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)
GO:1902041 (regulation of extrinsic apoptotic signaling pathway via death domain receptors)
GO:1902042 (negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)
Wikipedia TNFRSF10A

Target Cross References - Protein

Human Protein Atlas ENSG00000104689
IntAct O00220
Guide to Pharmacology 1879
Open Targets ENSG00000104689
PharmGKB PA36597
Reactome R-HSA-140534 (Ligand-dependent caspase activation.)
R-HSA-202733 (Cell surface interactions at the vascular wall.)
R-HSA-3371378 (Regulation by c-FLIP.)
R-HSA-5213460 (RIPK1-mediated regulated necrosis.)
R-HSA-5218900 (CASP8 activity is inhibited.)
R-HSA-6803211 (TP53 Regulates Transcription of Death Receptors and Ligands.)
R-HSA-69416 (Dimerization of procaspase-8.)
R-HSA-75158 (TRAIL signaling.)
UniProt A8K5I4 O00220 Q53Y72 Q96E62

Target Cross References - Domain

InterPro IPR000488 (Death_domain.)
IPR001368 (TNFR/NGFR_Cys_rich_reg.)
IPR011029 (DEATH-like_dom_sf.)
IPR020465 (TNFR_10.)
IPR034024 (TNFRSF10_N.)
IPR034029 (TNFRSF10A/B_death.)
Pfam PF00020 (TNFR_c6)
PF00531 (Death)

Target Cross References - Structure

PDBe 5CIR
CREDO 5CIR
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