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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3544
Target Type SINGLE PROTEIN
Preferred Name Orphan nuclear receptor LRH-1
Synonyms Alpha-1-fetoprotein transcription factor | B1-binding factor | B1F | CPF | CYP7A promoter-binding factor | FTF | Hepatocytic transcription factor | LRH-1 | Liver receptor homolog 1 | NR5A2 | Nuclear receptor subfamily 5 group A member 2 | hB1F
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transcription factor > nuclear receptor > nuclear hormone receptor subfamily 5 > nuclear hormone receptor subfamily 5 group a > nuclear hormone receptor subfamily 5 group a member 2

Target Components

Component Description Relationship Accession
Nuclear receptor subfamily 5 group A member 2 SINGLE PROTEIN O00482

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000116833
Ensembl ENSG00000116833
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0090575 (RNA polymerase II transcription factor complex)
GO Molecular Function GO:0000976 (transcription regulatory region sequence-specific DNA binding)
GO:0000978 (RNA polymerase II core promoter proximal region sequence-specific DNA binding)
GO:0000980 (RNA polymerase II distal enhancer sequence-specific DNA binding)
GO:0001077 (transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding)
GO:0003677 (DNA binding)
GO:0003682 (chromatin binding)
GO:0003690 (double-stranded DNA binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0003705 (transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding)
GO:0003707 (steroid hormone receptor activity)
GO:0004879 (RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding)
GO:0005515 (protein binding)
GO:0005543 (phospholipid binding)
GO:0008270 (zinc ion binding)
GO:0008289 (lipid binding)
GO:0043565 (sequence-specific DNA binding)
GO:0044212 (transcription regulatory region DNA binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006366 (transcription from RNA polymerase II promoter)
GO:0006367 (transcription initiation from RNA polymerase II promoter)
GO:0008206 (bile acid metabolic process)
GO:0009755 (hormone-mediated signaling pathway)
GO:0009790 (embryo development)
GO:0009888 (tissue development)
GO:0030522 (intracellular receptor signaling pathway)
GO:0030855 (epithelial cell differentiation)
GO:0042127 (regulation of cell proliferation)
GO:0042592 (homeostatic process)
GO:0042632 (cholesterol homeostasis)
GO:0043401 (steroid hormone mediated signaling pathway)
GO:0045070 (positive regulation of viral genome replication)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0061113 (pancreas morphogenesis)
Wikipedia Liver_receptor_homolog-1

Target Cross References - Protein

canSAR O00482
Human Protein Atlas ENSG00000116833
IntAct O00482
Open Targets ENSG00000116833
PharmGKB PA31765
Pharos O00482 (Tchem)
Reactome R-HSA-210747 (Regulation of gene expression in early pancreatic precursor cells.)
R-HSA-383280 (Nuclear Receptor transcription pathway.)
UniProt B4E2P3 O00482 O95642 Q147U3

Target Cross References - Domain

InterPro IPR000536 (Nucl_hrmn_rcpt_lig-bd.)
IPR001628 (Znf_hrmn_rcpt.)
IPR001723 (Nuclear_hrmn_rcpt.)
IPR013088 (Znf_NHR/GATA.)
IPR016355 (NR5_fam.)
Pfam PF00104 (Hormone_recep)
PF00105 (zf-C4)

Target Cross References - Structure

PDBe 1YOK 1YUC 1ZDU 2A66 3PLZ 3TX7 4DOR 4DOS 4IS8 4ONI 4PLD 4PLE 4RWV 5L0M 5L11 5SYZ
CREDO 1YOK 1YUC 1ZDU 2A66 3PLZ 3TX7 4DOR 4DOS 4IS8 4ONI 4PLD 4PLE 4RWV 5L0M 5L11 5SYZ
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