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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3544
Target Type SINGLE PROTEIN
Preferred Name Orphan nuclear receptor LRH-1
Synonyms Alpha-1-fetoprotein transcription factor | B1-binding factor | B1F | CPF | CYP7A promoter-binding factor | FTF | Hepatocytic transcription factor | LRH-1 | Liver receptor homolog 1 | NR5A2 | Nuclear receptor subfamily 5 group A member 2 | hB1F
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transcription factor > nuclear receptor > nuclear hormone receptor subfamily 5 > nuclear hormone receptor subfamily 5 group a > nuclear hormone receptor subfamily 5 group a member 2

Target Components

Component Description Relationship Accession
Nuclear receptor subfamily 5 group A member 2 SINGLE PROTEIN O00482

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000116833
Ensembl ENSG00000116833
GO Cellular Component GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO Molecular Function GO:0003705 (sequence-specific enhancer binding RNA polymerase II transcription factor activity)
GO:0003707 (steroid hormone receptor activity)
GO:0005515 (protein binding)
GO:0008270 (zinc ion binding)
GO:0008289 (lipid binding)
GO:0010843 (promoter binding)
GO:0043565 (sequence-specific DNA binding)
GO Biological Process GO:0009790 (embryo development)
GO:0034339 (regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor)
GO:0045070 (positive regulation of viral genome replication)
Wikipedia Liver_receptor_homolog-1

Target Cross References - Protein

canSAR O00482
Human Protein Atlas ENSG00000116833
IntAct O00482
Guide to Pharmacology 633 (Liver receptor homolog-1)
PharmGKB PA31765
Reactome REACT_13698 (Regulation of beta-cell development.)
REACT_71 (Gene Expression.)
UniProt O00482 O95642 Q147U3

Target Cross References - Domain

InterPro IPR000536 (Nucl_hrmn_rcpt_lig-bd_core.)
IPR001628 (Znf_hrmn_rcpt.)
IPR001723 (Str_hrmn_rcpt.)
IPR008946 (Nucl_hormone_rcpt_ligand-bd.)
IPR013088 (Znf_NHR/GATA.)
IPR016355 (Steroidogenic_factor_1.)
Pfam PF00104 (Hormone_recep)
PF00105 (zf-C4)

Target Cross References - Structure

PDBe 1YOK 1YUC 1ZDU 2A66 3PLZ
CREDO 1YOK 1YUC 1ZDU 2A66 3PLZ
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