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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3535
Target Type SINGLE PROTEIN
Preferred Name Phosphodiesterase 9A
Synonyms High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | PDE9A
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > phosphodiesterase > phosphodiesterase 9 > phosphodiesterase 9a

Target Components

Component Description Relationship Accession
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A SINGLE PROTEIN O76083

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2363066 3',5'-cyclic phosphodiesterase PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000160191
Ensembl ENSG00000160191
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005783 (endoplasmic reticulum)
GO:0005794 (Golgi apparatus)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0032587 (ruffle membrane)
GO:0042383 (sarcolemma)
GO:0042995 (cell projection)
GO:0043204 (perikaryon)
GO:0048471 (perinuclear region of cytoplasm)
GO Molecular Function GO:0004114 (3',5'-cyclic-nucleotide phosphodiesterase activity)
GO:0005515 (protein binding)
GO:0008081 (phosphoric diester hydrolase activity)
GO:0016787 (hydrolase activity)
GO:0046872 (metal ion binding)
GO:0047555 (3',5'-cyclic-GMP phosphodiesterase activity)
GO Biological Process GO:0007165 (signal transduction)
GO:0010613 (positive regulation of cardiac muscle hypertrophy)
GO:0019934 (cGMP-mediated signaling)
GO:0046068 (cGMP metabolic process)
GO:0046069 (cGMP catabolic process)
Wikipedia PDE9A

Target Cross References - Protein

canSAR O76083
Human Protein Atlas ENSG00000160191
IntAct O76083
Guide to Pharmacology 1309
Open Targets ENSG00000160191
PharmGKB PA33143
Reactome R-HSA-418457 (cGMP effects.)
UniProt B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O76083 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0

Target Cross References - Domain

InterPro IPR002073 (PDEase_catalytic_dom.)
IPR003607 (HD/PDEase_dom.)
IPR023088 (PDEase.)
IPR023174 (PDEase_CS.)
Pfam PF00233 (PDEase_I)

Target Cross References - Structure

PDBe 2HD1 2YY2 3DY8 3DYL 3DYN 3DYQ 3DYS 3JSI 3JSW 3K3E 3K3H 3N3Z 3QI3 3QI4 4E90 4G2J 4G2L 4GH6 4Y86 4Y87 4Y8C
CREDO 2HD1 2YY2 3DY8 3DYL 3DYN 3DYQ 3DYS 3JSI 3JSW 3K3E 3K3H 3N3Z 3QI3 3QI4 4E90 4G2J 4G2L 4GH6 4Y86 4Y87 4Y8C
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