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Target Report Card

Target Name and Classification

Target ID CHEMBL3530
Preferred Name Dual specificity mitogen-activated protein kinase kinase 7
Synonyms Dual specificity mitogen-activated protein kinase kinase 7 | JNK kinase 2 | JNK-activating kinase 2 | JNKK 2 | JNKK2 | MAP kinase kinase 7 | MAP2K7 | MAPK/ERK kinase 7 | MAPKK 7 | MEK 7 | MEK7 | MKK7 | PRKMK7 | SAPK kinase 4 | SAPKK-4 | SAPKK4 | SKK4 | Stress-activated protein kinase kinase 4 | c-Jun N-terminal kinase kinase 2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > ste protein kinase group > ste protein kinase ste7 family

Target Components

Component Description Relationship Accession
Dual specificity mitogen-activated protein kinase kinase 7 SINGLE PROTEIN O14733

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000076984
Ensembl ENSG00000076984
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0000287 (magnesium ion binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004708 (MAP kinase kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0019899 (enzyme binding)
GO:0019901 (protein kinase binding)
GO:0019903 (protein phosphatase binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0006915 (apoptotic process)
GO:0006970 (response to osmotic stress)
GO:0007165 (signal transduction)
GO:0007254 (JNK cascade)
GO:0007257 (activation of JUN kinase activity)
GO:0007346 (regulation of mitotic cell cycle)
GO:0009408 (response to heat)
GO:0009411 (response to UV)
GO:0016310 (phosphorylation)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0032212 (positive regulation of telomere maintenance via telomerase)
GO:0034612 (response to tumor necrosis factor)
GO:0035897 (proteolysis in other organism)
GO:0038095 (Fc-epsilon receptor signaling pathway)
GO:0042981 (regulation of apoptotic process)
GO:0051403 (stress-activated MAPK cascade)
GO:0051973 (positive regulation of telomerase activity)
GO:1904355 (positive regulation of telomere capping)
Wikipedia MAP2K7

Target Cross References - Protein

canSAR O14733
Human Protein Atlas ENSG00000076984
IntAct O14733
Guide to Pharmacology 2068
Open Targets ENSG00000076984
PharmGKB PA284
Pharos O14733 (Tbio)
Reactome R-HSA-2559580 (Oxidative Stress Induced Senescence.)
R-HSA-2871796 (FCERI mediated MAPK activation.)
R-HSA-450321 (JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.)
R-HSA-5210891 (Uptake and function of anthrax toxins.)
UniProt B2R9S5 D6W659 O14648 O14733 O14816 O60452 O60453 Q1PG43 Q8IY10

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
Pfam PF00069 (Pkinase)

Target Cross References - Structure

PDBe 2DYL 3WZU 4UX9 5B2K 5B2L 5B2M 5Y8U 5Y90
CREDO 2DYL 3WZU 4UX9 5B2K 5B2L 5B2M 5Y8U 5Y90