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Target Report Card

Target Name and Classification

Target ID CHEMBL3530
Preferred Name Dual specificity mitogen-activated protein kinase kinase 7
Synonyms Dual specificity mitogen-activated protein kinase kinase 7 | JNK kinase 2 | JNK-activating kinase 2 | JNKK 2 | JNKK2 | MAP kinase kinase 7 | MAP2K7 | MAPK/ERK kinase 7 | MAPKK 7 | MEK 7 | MEK7 | MKK7 | PRKMK7 | SAPK kinase 4 | SAPKK-4 | SAPKK4 | SKK4 | Stress-activated protein kinase kinase 4 | c-Jun N-terminal kinase kinase 2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > ste protein kinase group > ste protein kinase ste7 family

Target Components

Component Description Relationship Accession
Dual specificity mitogen-activated protein kinase kinase 7 SINGLE PROTEIN O14733

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000076984
Ensembl ENSG00000076984
GO Cellular Component GO:0005634 (nucleus)
GO:0005829 (cytosol)
GO Molecular Function GO:0000287 (magnesium ion binding)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0008545 (JUN kinase kinase activity)
GO:0019901 (protein kinase binding)
GO:0019903 (protein phosphatase binding)
GO Biological Process GO:0002755 (MyD88-dependent toll-like receptor signaling pathway)
GO:0002756 (MyD88-independent toll-like receptor signaling pathway)
GO:0007257 (activation of JUN kinase activity)
GO:0008063 (Toll signaling pathway)
GO:0034130 (toll-like receptor 1 signaling pathway)
GO:0034134 (toll-like receptor 2 signaling pathway)
GO:0034138 (toll-like receptor 3 signaling pathway)
GO:0034142 (toll-like receptor 4 signaling pathway)
GO:0045087 (innate immune response)
GO:0051403 (stress-activated MAPK cascade)
Wikipedia MAP2K7

Target Cross References - Protein

canSAR O14733
Human Protein Atlas ENSG00000076984
IntAct O14733
Guide to Pharmacology 2068 (mitogen-activated protein kinase kinase 7)
PharmGKB PA284
Reactome REACT_6900 (Signaling in Immune system.)
UniProt B2R9S5 D6W659 O14648 O14733 O14816 O60452 O60453 Q1PG43 Q8IY10

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_cat_dom.)
IPR002290 (Ser/Thr_prot_kinase_dom.)
IPR008271 (Ser/Thr_prot_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017442 (Se/Thr_prot_kinase-like_dom.)
Pfam PF00069 (Pkinase)

Target Cross References - Structure