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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3529
Target Type SINGLE PROTEIN
Preferred Name Inhibitor of nuclear factor kappa B kinase epsilon subunit
Synonyms I-kappa-B kinase epsilon | IKBKE | IKK-E | IKK-epsilon | IKK-i | IKKE | IKKI | IkBKE | Inducible I kappa-B kinase | Inhibitor of nuclear factor kappa-B kinase subunit epsilon | KIAA0151
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > other protein kinase group

Target Components

Component Description Relationship Accession
Inhibitor of nuclear factor kappa-B kinase subunit epsilon SINGLE PROTEIN Q14164

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3038486 IKK epsilon/TBK1 PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000143466
Ensembl ENSG00000143466
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0010008 (endosome membrane)
GO:0016605 (PML body)
GO:0031966 (mitochondrial membrane)
GO Molecular Function GO:0004704 (NF-kappaB-inducing kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0008384 (IkappaB kinase activity)
GO:0031625 (ubiquitin protein ligase binding)
GO:0036435 (K48-linked polyubiquitin binding)
GO Biological Process GO:0002224 (toll-like receptor signaling pathway)
GO:0002756 (MyD88-independent toll-like receptor signaling pathway)
GO:0006468 (protein phosphorylation)
GO:0006955 (immune response)
GO:0008063 (Toll signaling pathway)
GO:0008630 (DNA damage response, signal transduction resulting in induction of apoptosis)
GO:0008630 (intrinsic apoptotic signaling pathway in response to DNA damage)
GO:0032480 (negative regulation of type I interferon production)
GO:0034138 (toll-like receptor 3 signaling pathway)
GO:0034142 (toll-like receptor 4 signaling pathway)
GO:0034340 (response to type I interferon)
GO:0035456 (response to interferon-beta)
GO:0035666 (TRIF-dependent toll-like receptor signaling pathway)
GO:0038061 (NIK/NF-kappaB signaling)
GO:0043123 (positive regulation of I-kappaB kinase/NF-kappaB cascade)
GO:0043123 (positive regulation of I-kappaB kinase/NF-kappaB signaling)
GO:0045087 (innate immune response)
GO:0051260 (protein homooligomerization)
GO:0098586 (cellular response to virus)
Wikipedia IKBKE

Target Cross References - Protein

canSAR Q14164
Human Protein Atlas ENSG00000143466
IntAct Q14164
PharmGKB PA134962294
UniProt D3DT78 Q14164 Q3KR43 Q5JTS6

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_cat_dom.)
IPR000719 (Prot_kinase_dom.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR017442 (Se/Thr_prot_kinase-like_dom.)
Pfam PF00069 (Pkinase)
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