ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL3529
Target Type SINGLE PROTEIN
Preferred Name Inhibitor of nuclear factor kappa B kinase epsilon subunit
Synonyms I-kappa-B kinase epsilon | IKBKE | IKK-E | IKK-epsilon | IKK-i | IKKE | IKKI | IkBKE | Inducible I kappa-B kinase | Inhibitor of nuclear factor kappa-B kinase subunit epsilon | KIAA0151
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > other protein kinase group

Target Components

Component Description Relationship Accession
Inhibitor of nuclear factor kappa-B kinase subunit epsilon SINGLE PROTEIN Q14164

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3038486 IKK epsilon/TBK1 PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000263528
Ensembl ENSG00000263528
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0010008 (endosome membrane)
GO:0016605 (PML body)
GO:0031966 (mitochondrial membrane)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004704 (NF-kappaB-inducing kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0008384 (IkappaB kinase activity)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0031625 (ubiquitin protein ligase binding)
GO:0036435 (K48-linked polyubiquitin binding)
GO:0070530 (K63-linked polyubiquitin binding)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0006955 (immune response)
GO:0006974 (cellular response to DNA damage stimulus)
GO:0007252 (I-kappaB phosphorylation)
GO:0008630 (intrinsic apoptotic signaling pathway in response to DNA damage)
GO:0016310 (phosphorylation)
GO:0032480 (negative regulation of type I interferon production)
GO:0034340 (response to type I interferon)
GO:0035456 (response to interferon-beta)
GO:0035666 (TRIF-dependent toll-like receptor signaling pathway)
GO:0038061 (NIK/NF-kappaB signaling)
GO:0043123 (positive regulation of I-kappaB kinase/NF-kappaB signaling)
GO:0051260 (protein homooligomerization)
GO:0098586 (cellular response to virus)
Wikipedia IKBKE

Target Cross References - Protein

canSAR Q14164
Human Protein Atlas ENSG00000263528
IntAct Q14164
Guide to Pharmacology 2040
Open Targets ENSG00000263528
PharmGKB PA134962294
Pharos Q14164 (Tchem)
Reactome R-HSA-918233 (TRAF3-dependent IRF activation pathway.)
R-HSA-933541 (TRAF6 mediated IRF7 activation.)
R-HSA-936440 (Negative regulators of RIG-I/MDA5 signaling.)
R-HSA-936964 (Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon.)
UniProt D3DT78 Q14164 Q3B754 Q3KR43 Q5JTS6

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF00069 (Pkinase)
spacer
spacer