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Target Report Card

Target Name and Classification

Target ID CHEMBL3525
Preferred Name Integrin alpha-3
Synonyms CD49 antigen-like family member C | CD_antigen=CD49c | FRP-2 | GAPB3 | Galactoprotein B3 | ITGA3 | Integrin alpha-3 heavy chain | Integrin alpha-3 light chain | Integrin alpha-3 | MSK18 | VLA-3 subunit alpha
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor

Target Components

Component Description Relationship Accession
Integrin alpha-3 SINGLE PROTEIN P26006

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3883284 Integrin alpha-3/beta-3 PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000005884
Ensembl ENSG00000005884
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005925 (focal adhesion)
GO:0008305 (integrin complex)
GO:0009897 (external side of plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016323 (basolateral plasma membrane)
GO:0030054 (cell junction)
GO:0030426 (growth cone)
GO:0031527 (filopodium membrane)
GO:0034667 (integrin alpha3-beta1 complex)
GO:0042995 (cell projection)
GO:0043235 (receptor complex)
GO:0045202 (synapse)
GO:0048471 (perinuclear region of cytoplasm)
GO:0060076 (excitatory synapse)
GO:0070062 (extracellular exosome)
GO:0071438 (invadopodium membrane)
GO:0071944 (cell periphery)
GO:0097060 (synaptic membrane)
GO Molecular Function GO:0001968 (fibronectin binding)
GO:0002020 (protease binding)
GO:0005178 (integrin binding)
GO:0005515 (protein binding)
GO:0005518 (collagen binding)
GO:0019904 (protein domain specific binding)
GO:0043236 (laminin binding)
GO:0046872 (metal ion binding)
GO:0046982 (protein heterodimerization activity)
GO Biological Process GO:0001764 (neuron migration)
GO:0007155 (cell adhesion)
GO:0007160 (cell-matrix adhesion)
GO:0007229 (integrin-mediated signaling pathway)
GO:0007507 (heart development)
GO:0007613 (memory)
GO:0010628 (positive regulation of gene expression)
GO:0010634 (positive regulation of epithelial cell migration)
GO:0010811 (positive regulation of cell-substrate adhesion)
GO:0010976 (positive regulation of neuron projection development)
GO:0017015 (regulation of transforming growth factor beta receptor signaling pathway)
GO:0030111 (regulation of Wnt signaling pathway)
GO:0030198 (extracellular matrix organization)
GO:0030324 (lung development)
GO:0030510 (regulation of BMP signaling pathway)
GO:0031345 (negative regulation of cell projection organization)
GO:0034698 (response to gonadotropin)
GO:0035024 (negative regulation of Rho protein signal transduction)
GO:0035640 (exploration behavior)
GO:0042493 (response to drug)
GO:0043588 (skin development)
GO:0048333 (mesodermal cell differentiation)
GO:0050900 (leukocyte migration)
GO:0060135 (maternal process involved in female pregnancy)
GO:0072006 (nephron development)
GO:0097062 (dendritic spine maintenance)
GO:0097205 (renal filtration)
GO:1903078 (positive regulation of protein localization to plasma membrane)
Wikipedia CD49c

Target Cross References - Protein

CGD Interstitial lung disease with nephrotic syndrome and epidermolysis bullosa
Human Protein Atlas ENSG00000005884
IntAct P26006
Guide to Pharmacology 2442
Open Targets ENSG00000005884
PharmGKB PA29939
Reactome R-HSA-210991 (Basigin interactions.)
R-HSA-216083 (Integrin cell surface interactions.)
R-HSA-3000157 (Laminin interactions.)
R-HSA-8874081 (MET activates PTK2 signaling.)
TIMBAL Integrins
UniProt A7E246 B7ZM80 B9EGQ1 D3DTX4 D3DTX5 P26006

Target Cross References - Domain

InterPro IPR000413 (Integrin_alpha.)
IPR013517 (FG-GAP.)
IPR013519 (Int_alpha_beta-p.)
IPR013649 (Integrin_alpha-2.)
IPR018184 (Integrin_alpha_C_CS.)
IPR028994 (Integrin_alpha_N.)
IPR032695 (Integrin_dom_sf.)
Pfam PF01839 (FG-GAP)
PF08441 (Integrin_alpha2)