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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3525
Preferred Name Integrin alpha-3
Synonyms CD49 antigen-like family member C | CD_antigen=CD49c | FRP-2 | GAPB3 | Galactoprotein B3 | ITGA3 | Integrin alpha-3 | Integrin alpha-3 heavy chain | Integrin alpha-3 light chain | MSK18 | VLA-3 subunit alpha
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor

Target Components

Component Description Relationship Accession
Integrin alpha-3 SINGLE PROTEIN P26006

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000005884
Ensembl ENSG00000005884
GO Cellular Component GO:0008305 (integrin complex)
GO:0009986 (cell surface)
GO Molecular Function GO:0004872 (receptor activity)
GO:0005515 (protein binding)
GO Biological Process GO:0007160 (cell-matrix adhesion)
GO:0007229 (integrin-mediated signaling pathway)
GO:0007596 (blood coagulation)
GO:0050900 (leukocyte migration)
Wikipedia CD49c

Target Cross References - Protein

CGD Interstitial lung disease with nephrotic syndrome and epidermolysis bullosa
Human Protein Atlas ENSG00000005884
IntAct P26006
Guide to Pharmacology 2442 (integrin, alpha 3 subunit (antigen CD49C, alpha 3 subunit of VLA-3 receptor))
PharmGKB PA29939
Reactome REACT_13552 (Integrin cell surface interactions.)
REACT_604 (Hemostasis.)
TIMBAL Integrins
UniProt A7E246 B7ZM80 B9EGQ1 D3DTX4 D3DTX5 P26006

Target Cross References - Domain

InterPro IPR000413 (Integrin_alpha.)
IPR013517 (FG-GAP.)
IPR013519 (Int_alpha_beta-p.)
IPR013649 (Integrin_alpha-2.)
Pfam PF01839 (FG-GAP)
PF08441 (Integrin_alpha2)