ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL3524
Target Type SINGLE PROTEIN
Preferred Name Histone deacetylase 4
Synonyms HD4 | HDAC4 | Histone deacetylase 4 | KIAA0288
Organism Homo sapiens
Species Group No
Protein Target Classification
  • epigenetic regulator > eraser > histone deacetylase > hdac class iia

Target Components

Component Description Relationship Accession
Histone deacetylase 4 SINGLE PROTEIN P56524

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2093865 Histone deacetylase PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000068024
Ensembl ENSG00000068024
GO Cellular Component GO:0000118 (histone deacetylase complex)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0017053 (transcriptional repressor complex)
GO:0030017 (sarcomere)
GO:0030018 (Z disc)
GO:0031594 (neuromuscular junction)
GO:0031672 (A band)
GO:0032991 (macromolecular complex)
GO:0042641 (actomyosin)
GO Molecular Function GO:0001047 (core promoter binding)
GO:0001085 (RNA polymerase II transcription factor binding)
GO:0003677 (DNA binding)
GO:0003682 (chromatin binding)
GO:0003714 (transcription corepressor activity)
GO:0004407 (histone deacetylase activity)
GO:0005515 (protein binding)
GO:0008134 (transcription factor binding)
GO:0008270 (zinc ion binding)
GO:0016787 (hydrolase activity)
GO:0019901 (protein kinase binding)
GO:0030955 (potassium ion binding)
GO:0032041 (NAD-dependent histone deacetylase activity (H3-K14 specific))
GO:0033558 (protein deacetylase activity)
GO:0033613 (activating transcription factor binding)
GO:0042802 (identical protein binding)
GO:0042826 (histone deacetylase binding)
GO:0043565 (sequence-specific DNA binding)
GO:0044212 (transcription regulatory region DNA binding)
GO:0046872 (metal ion binding)
GO:0070491 (repressing transcription factor binding)
GO:1990841 (promoter-specific chromatin binding)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0001501 (skeletal system development)
GO:0002076 (osteoblast development)
GO:0006325 (chromatin organization)
GO:0006338 (chromatin remodeling)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006476 (protein deacetylation)
GO:0006954 (inflammatory response)
GO:0007399 (nervous system development)
GO:0008284 (positive regulation of cell proliferation)
GO:0008285 (negative regulation of cell proliferation)
GO:0010592 (positive regulation of lamellipodium assembly)
GO:0010832 (negative regulation of myotube differentiation)
GO:0010882 (regulation of cardiac muscle contraction by calcium ion signaling)
GO:0014894 (response to denervation involved in regulation of muscle adaptation)
GO:0014898 (cardiac muscle hypertrophy in response to stress)
GO:0014911 (positive regulation of smooth muscle cell migration)
GO:0016575 (histone deacetylation)
GO:0030183 (B cell differentiation)
GO:0033235 (positive regulation of protein sumoylation)
GO:0034983 (peptidyl-lysine deacetylation)
GO:0040029 (regulation of gene expression, epigenetic)
GO:0042113 (B cell activation)
GO:0042493 (response to drug)
GO:0043393 (regulation of protein binding)
GO:0043433 (negative regulation of sequence-specific DNA binding transcription factor activity)
GO:0043525 (positive regulation of neuron apoptotic process)
GO:0045668 (negative regulation of osteoblast differentiation)
GO:0045820 (negative regulation of glycolytic process)
GO:0045892 (negative regulation of transcription, DNA-templated)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0048661 (positive regulation of smooth muscle cell proliferation)
GO:0048742 (regulation of skeletal muscle fiber development)
GO:0051091 (positive regulation of sequence-specific DNA binding transcription factor activity)
GO:0051153 (regulation of striated muscle cell differentiation)
GO:0070555 (response to interleukin-1)
GO:0070932 (histone H3 deacetylation)
GO:0070933 (histone H4 deacetylation)
GO:0071260 (cellular response to mechanical stimulus)
GO:0071356 (cellular response to tumor necrosis factor)
GO:0071374 (cellular response to parathyroid hormone stimulus)
GO:1902894 (negative regulation of pri-miRNA transcription from RNA polymerase II promoter)
GO:1903428 (positive regulation of reactive oxygen species biosynthetic process)
Wikipedia HDAC4

Target Cross References - Protein

canSAR P56524
CGD Brachydacytly-mental retardation syndrome
Human Protein Atlas ENSG00000068024
IntAct P56524
Guide to Pharmacology 2659
Open Targets ENSG00000068024
PharmGKB PA29229
Reactome R-HSA-2122947 (NOTCH1 Intracellular Domain Regulates Transcription.)
R-HSA-2644606 (Constitutive Signaling by NOTCH1 PEST Domain Mutants.)
R-HSA-2894862 (Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.)
R-HSA-4551638 (SUMOylation of chromatin organization proteins.)
R-HSA-8941284 (RUNX2 regulates chondrocyte maturation.)
R-HSA-8951936 (RUNX3 regulates p14-ARF.)
UniProt E9PGB9 F5GX36 P56524 Q86YH7 Q9UND6

Target Cross References - Domain

InterPro IPR000286 (His_deacetylse.)
IPR017320 (Histone_deAcase_II_euk.)
IPR023696 (Ureohydrolase_dom_sf.)
IPR023801 (His_deacetylse_dom.)
IPR024643 (Hist_deacetylase_Gln_rich_N.)
IPR033660 (HDAC4.)
IPR037138 (His_deacetylse_dom_sf.)
Pfam PF00850 (Hist_deacetyl)
PF12203 (HDAC4_Gln)

Target Cross References - Structure

PDBe 2H8N 2O94 2VQJ 2VQM 2VQO 2VQQ 2VQV 2VQW 3UXG 3UZD 3V31 4CBT 4CBY 5A2S
CREDO 2H8N 2O94 2VQJ 2VQM 2VQO 2VQQ 2VQV 2VQW 3UXG 3UZD 3V31 4CBT 4CBY 5A2S
spacer
spacer