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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3514
Target Type SINGLE PROTEIN
Preferred Name LDL-associated phospholipase A2
Synonyms 1-alkyl-2-acetylglycerophosphocholine esterase | 2-acetyl-1-alkylglycerophosphocholine esterase | Group-VIIA phospholipase A2 | LDL-PLA(2) | LDL-associated phospholipase A2 | PAF 2-acylhydrolase | PAF acetylhydrolase | PAFAH | PLA2G7 | Platelet-activating factor acetylhydrolase | gVIIA-PLA2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Platelet-activating factor acetylhydrolase SINGLE PROTEIN Q13093

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000146070
Ensembl ENSG00000146070
GO Cellular Component GO:0005615 (extracellular space)
GO Molecular Function GO:0003847 (1-alkyl-2-acetylglycerophosphocholine esterase activity)
GO:0005543 (phospholipid binding)
GO Biological Process GO:0006954 (inflammatory response)
GO:0016042 (lipid catabolic process)
Wikipedia Lipoprotein-associated_phospholipase_A2

Target Cross References - Protein

canSAR Q13093
CGD Platelet-activating factor acetylhydrolase deficiency
Human Protein Atlas ENSG00000146070
IntAct Q13093
Guide to Pharmacology 1432 (PLA2-G7)
PharmGKB PA33368
Reactome REACT_15380 (Diabetes pathways.)
UniProt A5HTT5 Q13093 Q15692 Q5VTT1 Q8IVA2

Target Cross References - Domain

InterPro IPR005065 (PAF_acetylhydro_II.)
IPR016715 (Ac_Ohase_PAF.)

Target Cross References - Structure

PDBe 3D59 3D5E 3F96 3F97 3F98 3F9C
CREDO 3D59 3D5E 3F96 3F97 3F98 3F9C
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