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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3514
Target Type SINGLE PROTEIN
Preferred Name LDL-associated phospholipase A2
Synonyms 1-alkyl-2-acetylglycerophosphocholine esterase | 2-acetyl-1-alkylglycerophosphocholine esterase | Group-VIIA phospholipase A2 | LDL-PLA(2) | LDL-associated phospholipase A2 | PAF 2-acylhydrolase | PAF acetylhydrolase | PAFAH | PLA2G7 | Platelet-activating factor acetylhydrolase | gVIIA-PLA2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Platelet-activating factor acetylhydrolase SINGLE PROTEIN Q13093

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL204021 DARAPLADIB LDL-associated phospholipase A2 inhibitor 3 PubMed
CHEMBL2104981 RILAPLADIB LDL-associated phospholipase A2 inhibitor 2 PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000146070
Ensembl ENSG00000146070
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005737 (cytoplasm)
GO:0034362 (low-density lipoprotein particle)
GO Molecular Function GO:0003847 (1-alkyl-2-acetylglycerophosphocholine esterase activity)
GO:0005543 (phospholipid binding)
GO:0016787 (hydrolase activity)
GO:0016788 (hydrolase activity, acting on ester bonds)
GO:0047499 (calcium-independent phospholipase A2 activity)
GO Biological Process GO:0006629 (lipid metabolic process)
GO:0016042 (lipid catabolic process)
GO:0034374 (low-density lipoprotein particle remodeling)
GO:0034440 (lipid oxidation)
GO:0034441 (plasma lipoprotein particle oxidation)
GO:0050729 (positive regulation of inflammatory response)
GO:0090026 (positive regulation of monocyte chemotaxis)
Wikipedia Lipoprotein-associated_phospholipase_A2

Target Cross References - Protein

canSAR Q13093
CGD Platelet-activating factor acetylhydrolase deficiency
Human Protein Atlas ENSG00000146070
IntAct Q13093
Guide to Pharmacology 1432
Open Targets ENSG00000146070
PharmGKB PA33368
Reactome R-HSA-422085 (Synthesis, secretion, and deacylation of Ghrelin.)
UniProt A5HTT5 Q13093 Q15692 Q5VTT1 Q8IVA2

Target Cross References - Domain

InterPro IPR005065 (PAF_acetylhydro-like.)
IPR016715 (PAF_acetylhydro_eukaryote.)
IPR029058 (AB_hydrolase.)
Pfam PF03403 (PAF-AH_p_II)

Target Cross References - Structure

PDBe 3D59 3D5E 3F96 3F97 3F98 3F9C 5I8P 5I9I 5JAD 5JAH 5JAL 5JAN 5JAO 5JAP 5JAR 5JAS 5JAT 5JAU 5LP1 5LYY 5LZ2 5LZ4 5LZ5 5LZ7 More...
CREDO 3D59 3D5E 3F96 3F97 3F98 3F9C 5I8P 5I9I 5JAD 5JAH 5JAL 5JAN 5JAO 5JAP 5JAR 5JAS 5JAT 5JAU 5LP1 5LYY 5LZ2 5LZ4 5LZ5 5LZ7 More...
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