ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL3491
Target Type SINGLE PROTEIN
Preferred Name Cytochrome P450 2J2
Synonyms Arachidonic acid epoxygenase | CYP2J2 | CYPIIJ2 | Cytochrome P450 2J2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Cytochrome P450 2J2 SINGLE PROTEIN P51589

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000134716
Ensembl ENSG00000134716
GO Cellular Component GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0016020 (membrane)
GO:0031090 (organelle membrane)
GO:0043231 (intracellular membrane-bounded organelle)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0004497 (monooxygenase activity)
GO:0005506 (iron ion binding)
GO:0008392 (arachidonic acid epoxygenase activity)
GO:0008395 (steroid hydroxylase activity)
GO:0008404 (arachidonic acid 14,15-epoxygenase activity)
GO:0008405 (arachidonic acid 11,12-epoxygenase activity)
GO:0016491 (oxidoreductase activity)
GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen)
GO:0016712 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen)
GO:0020037 (heme binding)
GO:0046872 (metal ion binding)
GO:0070330 (aromatase activity)
GO:0071614 (linoleic acid epoxygenase activity)
GO Biological Process GO:0006690 (icosanoid metabolic process)
GO:0006805 (xenobiotic metabolic process)
GO:0008016 (regulation of heart contraction)
GO:0019373 (epoxygenase P450 pathway)
GO:0043651 (linoleic acid metabolic process)
GO:0055114 (oxidation-reduction process)
Wikipedia CYP2J2

Target Cross References - Protein

canSAR P51589
Human Protein Atlas ENSG00000134716
IntAct P51589
Guide to Pharmacology 1332
Open Targets ENSG00000134716
PharmGKB PA27112
Reactome R-HSA-211935 (Fatty acids.)
R-HSA-211981 (Xenobiotics.)
R-HSA-2142670 (Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).)
UniProt B2RD33 P51589 Q8TF13

Target Cross References - Domain

InterPro IPR001128 (Cyt_P450.)
IPR002401 (Cyt_P450_E_grp-I.)
IPR008071 (Cyt_P450_E_grp-I_CYP2J-like.)
IPR017972 (Cyt_P450_CS.)
Pfam PF00067 (p450)
spacer
spacer