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Target Report Card

Target Name and Classification

Target ID CHEMBL3491
Preferred Name Cytochrome P450 2J2
Synonyms Arachidonic acid epoxygenase | CYP2J2 | CYPIIJ2 | Cytochrome P450 2J2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Cytochrome P450 2J2 SINGLE PROTEIN P51589

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000134716
Ensembl ENSG00000134716
GO Cellular Component GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0016020 (membrane)
GO:0031090 (organelle membrane)
GO:0043231 (intracellular membrane-bounded organelle)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0004497 (monooxygenase activity)
GO:0005506 (iron ion binding)
GO:0008392 (arachidonic acid epoxygenase activity)
GO:0008395 (steroid hydroxylase activity)
GO:0008404 (arachidonic acid 14,15-epoxygenase activity)
GO:0008405 (arachidonic acid 11,12-epoxygenase activity)
GO:0016491 (oxidoreductase activity)
GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen)
GO:0016712 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen)
GO:0020037 (heme binding)
GO:0046872 (metal ion binding)
GO:0070330 (aromatase activity)
GO:0071614 (linoleic acid epoxygenase activity)
GO Biological Process GO:0006690 (icosanoid metabolic process)
GO:0006805 (xenobiotic metabolic process)
GO:0008016 (regulation of heart contraction)
GO:0019373 (epoxygenase P450 pathway)
GO:0043651 (linoleic acid metabolic process)
GO:0055114 (oxidation-reduction process)
Wikipedia CYP2J2

Target Cross References - Protein

canSAR P51589
Human Protein Atlas ENSG00000134716
IntAct P51589
Guide to Pharmacology 1332
Open Targets ENSG00000134716
PharmGKB PA27112
Reactome R-HSA-211935 (Fatty acids.)
R-HSA-211981 (Xenobiotics.)
R-HSA-2142670 (Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).)
UniProt B2RD33 P51589 Q8TF13

Target Cross References - Domain

InterPro IPR001128 (Cyt_P450.)
IPR002401 (Cyt_P450_E_grp-I.)
IPR008071 (Cyt_P450_E_grp-I_CYP2J-like.)
IPR017972 (Cyt_P450_CS.)
Pfam PF00067 (p450)