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Target Report Card

Target Name and Classification

Target ID CHEMBL3473
Preferred Name C-C chemokine receptor type 3
Synonyms C-C CKR-3 | C-C chemokine receptor type 3 | CC-CKR-3 | CCR-3 | CCR3 | CCR3 | CD_antigen=CD193 | CKR3 | CMKBR3 | Eosinophil eotaxin receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > peptide receptor (family a gpcr) > chemokine receptor > cc chemokine receptor

Target Components

Component Description Relationship Accession
C-C chemokine receptor type 3 SINGLE PROTEIN P51677

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000183625
Ensembl ENSG00000183625
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004950 (chemokine receptor activity)
GO:0005515 (protein binding)
GO:0016493 (C-C chemokine receptor activity)
GO:0019957 (C-C chemokine binding)
GO Biological Process GO:0001938 (positive regulation of endothelial cell proliferation)
GO:0006935 (chemotaxis)
GO:0006954 (inflammatory response)
GO:0006968 (cellular defense response)
GO:0007155 (cell adhesion)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007188 (adenylate cyclase-modulating G-protein coupled receptor signaling pathway)
GO:0007204 (positive regulation of cytosolic calcium ion concentration)
GO:0016032 (viral process)
GO:0045766 (positive regulation of angiogenesis)
GO:0070098 (chemokine-mediated signaling pathway)
Wikipedia CCR3_(gene)

Target Cross References - Protein

canSAR P51677
Human Protein Atlas ENSG00000183625
IntAct P51677
Guide to Pharmacology 60
Open Targets ENSG00000183625
PharmGKB PA26168
Pharos P51677 (Tchem)
Reactome R-HSA-380108 (Chemokine receptors bind chemokines.)
R-HSA-418594 (G alpha (i) signalling events.)
UniProt B3KVQ1 F5GWL6 P51677 Q15748 Q2YDB9 Q86WD2 Q8TDP6 Q9ULY8

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000355 (Chemokine_rcpt.)
IPR002238 (Chemokine_CCR3.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)