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Target Report Card

Target Name and Classification

Target ID CHEMBL3468
Preferred Name Caspase-7
Synonyms Apoptotic protease Mch-3 | CASP-7 | CASP7 | CMH-1 | Caspase-7 | Caspase-7 subunit p11 | Caspase-7 subunit p20 | ICE-LAP3 | ICE-like apoptotic protease 3 | MCH3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > cysteine protease > cysteine protease cd clan > cysteine protease c14 family

Target Components

Component Description Relationship Accession
Caspase-7 SINGLE PROTEIN P55210

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000165806
Ensembl ENSG00000165806
GO Cellular Component GO:0005654 (nucleoplasm)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005829 (cytosol)
GO:0031966 (mitochondrial membrane)
GO Molecular Function GO:0004197 (cysteine-type endopeptidase activity)
GO:0005515 (protein binding)
GO Biological Process GO:0006508 (proteolysis)
GO:0006921 (cellular component disassembly involved in apoptosis)
GO:0008629 (induction of apoptosis by intracellular signals)
GO:0008635 (activation of caspase activity by cytochrome c)
Wikipedia Caspase_7

Target Cross References - Protein

canSAR P55210
Human Protein Atlas ENSG00000165806
IntAct P55210
Guide to Pharmacology 1623 (Caspase 7)
PharmGKB PA26091
Reactome REACT_578 (Apoptosis.)
UniProt B5BU45 D3DRB8 P55210 Q13364 Q53YD5 Q5SVL0 Q5SVL3 Q96BA0

Target Cross References - Domain

InterPro IPR001309 (Pept_C14_ICE_p20.)
IPR002138 (Pept_C14_p10.)
IPR002398 (Pept_C14_p45.)
IPR011600 (Pept_C14_cat.)
IPR015471 (Casp7.)
IPR015917 (Pept_C14_p45_core.)
IPR016129 (Pept_C14_ICE_p20_AS.)
Pfam PF00656 (Peptidase_C14)

Target Cross References - Structure

PDBe 1F1J 1GQF 1I4O 1I51 1K86 1K88 1KMC 1SHJ 1SHL 2QL5 2QL7 2QL9 2QLB 2QLF 2QLJ 3EDR 3H1P 3IBC 3IBF
CREDO 1F1J 1GQF 1I4O 1I51 1K86 1K88 1KMC 1SHJ 1SHL 2QL5 2QL7 2QL9 2QLB 2QLF 2QLJ 3EDR 3H1P 3IBC 3IBF