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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3468
Preferred Name Caspase-7
Synonyms Apoptotic protease Mch-3 | CASP-7 | CASP7 | CMH-1 | Caspase-7 subunit p11 | Caspase-7 subunit p20 | Caspase-7 | ICE-LAP3 | ICE-like apoptotic protease 3 | MCH3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > cysteine protease > cysteine protease cd clan > cysteine protease c14 family

Target Components

Component Description Relationship Accession
Caspase-7 SINGLE PROTEIN P55210

Target Relations

ChEMBL ID Pref Name Target Type

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000165806
Ensembl ENSG00000165806
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO Molecular Function GO:0004197 (cysteine-type endopeptidase activity)
GO:0005515 (protein binding)
GO:0008233 (peptidase activity)
GO:0008234 (cysteine-type peptidase activity)
GO:0016787 (hydrolase activity)
GO:0097200 (cysteine-type endopeptidase activity involved in execution phase of apoptosis)
GO Biological Process GO:0006508 (proteolysis)
GO:0006915 (apoptotic process)
GO:0006921 (cellular component disassembly involved in execution phase of apoptosis)
GO:0008635 (activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)
GO:0097194 (execution phase of apoptosis)
Wikipedia Caspase_7

Target Cross References - Protein

canSAR P55210
Human Protein Atlas ENSG00000165806
IntAct P55210
Guide to Pharmacology 1623
Open Targets ENSG00000165806
PharmGKB PA26091
Reactome R-HSA-111459 (Activation of caspases through apoptosome-mediated cleavage.)
R-HSA-111463 (SMAC binds to IAPs.)
R-HSA-111464 (SMAC-mediated dissociation of IAP:caspase complexes.)
R-HSA-111465 (Apoptotic cleavage of cellular proteins.)
R-HSA-264870 (Caspase-mediated cleavage of cytoskeletal proteins.)
UniProt B4DQU7 B5BU45 D3DRB8 P55210 Q13364 Q53YD5 Q5SVL0 Q5SVL3 Q96BA0

Target Cross References - Domain

InterPro IPR001309 (Pept_C14_p20.)
IPR002138 (Pept_C14_p10.)
IPR015917 (Pept_C14A.)
IPR016129 (Caspase_his_AS.)
IPR017350 (Pept_C14A_CASP1-typ.)
IPR029030 (Caspase-like_dom.)
IPR033139 (Caspase_cys_AS.)

Target Cross References - Structure

PDBe 1F1J 1GQF 1I4O 1I51 1K86 1K88 1KMC 1SHJ 1SHL 2QL5 2QL7 2QL9 2QLB 2QLF 2QLJ 3EDR 3H1P 3IBC 3IBF 3R5K 4FDL 4FEA 4HQ0 4HQR More...
CREDO 1F1J 1GQF 1I4O 1I51 1K86 1K88 1KMC 1SHJ 1SHL 2QL5 2QL7 2QL9 2QLB 2QLF 2QLJ 3EDR 3H1P 3IBC 3IBF 3R5K 4FDL 4FEA 4HQ0 4HQR More...