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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3467
Target Type SINGLE PROTEIN
Preferred Name P-glycoprotein 1
Synonyms ATP-binding cassette sub-family B member 1B | Abcb1 | Abcb1b | CD_antigen=CD243 | Mdr1 | Mdr1b | Multidrug resistance protein 1B | P-glycoprotein 1 | Pgy1 | Pgy1-1
Organism Mus musculus
Species Group No
Protein Target Classification
  • transporter > primary active transporter > atp-binding cassette > abcb subfamily

Target Components

Component Description Relationship Accession
Multidrug resistance protein 1B SINGLE PROTEIN P06795

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111404 P-glycoprotein 1 and 3 (MDR1a/MDR1b) PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005739 (mitochondrion)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0046581 (intercellular canaliculus)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0005524 (ATP binding)
GO:0008559 (xenobiotic-transporting ATPase activity)
GO:0016787 (hydrolase activity)
GO:0016887 (ATPase activity)
GO:0042626 (ATPase activity, coupled to transmembrane movement of substances)
GO Biological Process GO:0002481 (antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent)
GO:0002485 (antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent)
GO:0002489 (antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent)
GO:0002591 (positive regulation of antigen processing and presentation of peptide antigen via MHC class I)
GO:0006810 (transport)
GO:0006855 (drug transmembrane transport)
GO:0042908 (xenobiotic transport)
GO:0055085 (transmembrane transport)

Target Cross References - Protein

canSAR P06795
IntAct P06795
MICAD NBK23002 (P-glycoprotein multidrug transporter, MDR-1)
NBK23098 (P-glycoprotein, MDR-1, mitochondria)
NBK23105 (P-glycoprotein (Pgp), multidrug transporter)
NBK23188 (P-glycoprotein multidrug transporter, MDR-1)
NBK23561 (P-glycoprotein multidrug transporter, MDR-1)
NBK23721 (P-glycoprotein (P-gp) multidrug transporter, MDR-1)
NBK45979 (P-glycoprotein multidrug transporter, MDR-1)
NBK45980 (P-glycoprotein multidrug transporter, MDR-1)
Reactome R-MMU-382556 (ABC-family proteins mediated transport.)
UniProt P06795

Target Cross References - Domain

InterPro IPR003439 (ABC_transporter-like.)
IPR003593 (AAA+_ATPase.)
IPR011527 (ABC1_TM_dom.)
IPR017871 (ABC_transporter_CS.)
IPR027417 (P-loop_NTPase.)
Pfam PF00005 (ABC_tran)
PF00664 (ABC_membrane)
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