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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3438
Preferred Name Protein kinase C zeta
Synonyms PKC2 | PRKCZ | Protein kinase C zeta type | nPKC-zeta
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > agc protein kinase group > agc protein kinase pkc family > agc protein kinase pkc iota subfamily

Target Components

Component Description Relationship Accession
Protein kinase C zeta type SINGLE PROTEIN Q05513

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2093867 Protein kinase C (PKC) PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000067606
Ensembl ENSG00000067606
GO Cellular Component GO:0005768 (endosome)
GO Molecular Function GO:0004697 (protein kinase C activity)
GO:0005524 (ATP binding)
GO:0008270 (zinc ion binding)
GO Biological Process GO:0006916 (anti-apoptosis)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0030168 (platelet activation)
GO:0031333 (negative regulation of protein complex assembly)
GO:0035556 (intracellular signal transduction)
GO:0046627 (negative regulation of insulin receptor signaling pathway)
GO:0050732 (negative regulation of peptidyl-tyrosine phosphorylation)
Wikipedia Protein_kinase_M_zeta/Protein_kinase_C_zeta

Target Cross References - Protein

canSAR Q05513
Human Protein Atlas ENSG00000067606
IntAct Q05513
Guide to Pharmacology 1491 (protein kinase C, zeta)
PharmGKB PA33775
Reactome REACT_604 (Hemostasis.)
UniProt A8K4N0 A8MU64 Q05513 Q15207 Q5SYT5 Q969S4

Target Cross References - Domain

InterPro IPR000270 (OPR_PB1.)
IPR000719 (Prot_kinase_cat_dom.)
IPR000961 (AGC-kinase_C.)
IPR002219 (Prot_Kinase_C-like_PE/DAG-bd.)
IPR002290 (Ser/Thr_prot_kinase_dom.)
IPR008271 (Ser/Thr_prot_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR012233 (PKC_zeta.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR017442 (Se/Thr_prot_kinase-like_dom.)
IPR017892 (Pkinase_C.)
IPR020454 (DAG/PE-bd.)
Pfam PF00069 (Pkinase)
PF00130 (C1_1)
PF00433 (Pkinase_C)
PF00564 (PB1)