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Target Report Card

Target Name and Classification

Target ID CHEMBL3438
Target Type SINGLE PROTEIN
Preferred Name Protein kinase C zeta
Synonyms PKC2 | PRKCZ | Protein kinase C zeta type | nPKC-zeta
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > agc protein kinase group > agc protein kinase pkc family > agc protein kinase pkc iota subfamily

Target Components

Component Description Relationship Accession
Protein kinase C zeta type SINGLE PROTEIN Q05513

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2093867 Protein kinase C (PKC) PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000067606
Ensembl ENSG00000067606
GO Cellular Component GO:0005634 (nucleus)
GO:0005635 (nuclear envelope)
GO:0005737 (cytoplasm)
GO:0005768 (endosome)
GO:0005815 (microtubule organizing center)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005911 (cell-cell junction)
GO:0005923 (bicellular tight junction)
GO:0005938 (cell cortex)
GO:0016020 (membrane)
GO:0016324 (apical plasma membrane)
GO:0016363 (nuclear matrix)
GO:0030054 (cell junction)
GO:0031252 (cell leading edge)
GO:0031941 (filamentous actin)
GO:0031982 (vesicle)
GO:0035748 (myelin sheath abaxonal region)
GO:0043203 (axon hillock)
GO:0043231 (intracellular membrane-bounded organelle)
GO:0043234 (protein complex)
GO:0045121 (membrane raft)
GO:0045179 (apical cortex)
GO:0048471 (perinuclear region of cytoplasm)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004697 (protein kinase C activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0015459 (potassium channel regulator activity)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0019901 (protein kinase binding)
GO:0019904 (protein domain specific binding)
GO:0043274 (phospholipase binding)
GO:0043560 (insulin receptor substrate binding)
GO:0046872 (metal ion binding)
GO:0071889 (14-3-3 protein binding)
GO Biological Process GO:0000226 (microtubule cytoskeleton organization)
GO:0001954 (positive regulation of cell-matrix adhesion)
GO:0006468 (protein phosphorylation)
GO:0006954 (inflammatory response)
GO:0007165 (signal transduction)
GO:0007166 (cell surface receptor signaling pathway)
GO:0007179 (transforming growth factor beta receptor signaling pathway)
GO:0007616 (long-term memory)
GO:0008284 (positive regulation of cell proliferation)
GO:0008286 (insulin receptor signaling pathway)
GO:0016310 (phosphorylation)
GO:0016477 (cell migration)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0030010 (establishment of cell polarity)
GO:0031333 (negative regulation of protein complex assembly)
GO:0031532 (actin cytoskeleton reorganization)
GO:0031584 (activation of phospholipase D activity)
GO:0032148 (activation of protein kinase B activity)
GO:0032753 (positive regulation of interleukin-4 production)
GO:0032869 (cellular response to insulin stimulus)
GO:0034613 (cellular protein localization)
GO:0035556 (intracellular signal transduction)
GO:0043066 (negative regulation of apoptotic process)
GO:0045630 (positive regulation of T-helper 2 cell differentiation)
GO:0046326 (positive regulation of glucose import)
GO:0046627 (negative regulation of insulin receptor signaling pathway)
GO:0046628 (positive regulation of insulin receptor signaling pathway)
GO:0047496 (vesicle transport along microtubule)
GO:0050732 (negative regulation of peptidyl-tyrosine phosphorylation)
GO:0050806 (positive regulation of synaptic transmission)
GO:0051092 (positive regulation of NF-kappaB transcription factor activity)
GO:0051222 (positive regulation of protein transport)
GO:0051291 (protein heterooligomerization)
GO:0051346 (negative regulation of hydrolase activity)
GO:0051899 (membrane depolarization)
GO:0060081 (membrane hyperpolarization)
GO:0060291 (long-term synaptic potentiation)
GO:0070374 (positive regulation of ERK1 and ERK2 cascade)
GO:0070528 (protein kinase C signaling)
GO:0072659 (protein localization to plasma membrane)
GO:1990138 (neuron projection extension)
GO:2000463 (positive regulation of excitatory postsynaptic potential)
GO:2000553 (positive regulation of T-helper 2 cell cytokine production)
GO:2000664 (positive regulation of interleukin-5 secretion)
GO:2000667 (positive regulation of interleukin-13 secretion)
GO:2001181 (positive regulation of interleukin-10 secretion)
Wikipedia Protein_kinase_M_zeta/Protein_kinase_C_zeta

Target Cross References - Protein

canSAR Q05513
Human Protein Atlas ENSG00000067606
IntAct Q05513
Guide to Pharmacology 1491
Open Targets ENSG00000067606
PharmGKB PA33775
Pharos Q05513 (Tchem)
Reactome R-HSA-114604 (GPVI-mediated activation cascade.)
R-HSA-2173791 (TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition).)
R-HSA-5218921 (VEGFR2 mediated cell proliferation.)
UniProt A8K4N0 A8MU64 B7Z2J7 E9PCW2 Q05513 Q15207 Q5SYT5 Q969S4

Target Cross References - Domain

InterPro IPR000270 (PB1_dom.)
IPR000719 (Prot_kinase_dom.)
IPR000961 (AGC-kinase_C.)
IPR002219 (PE/DAG-bd.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR012233 (PKC.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR017892 (Pkinase_C.)
IPR020454 (DAG/PE-bd.)
Pfam PF00069 (Pkinase)
PF00130 (C1_1)
PF00433 (Pkinase_C)
PF00564 (PB1)
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