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Target Report Card

Target Name and Classification

Target ID CHEMBL3437
Preferred Name Amine oxidase, copper containing
Synonyms AOC3 | Copper amine oxidase | HPAO | Membrane primary amine oxidase | SSAO | Semicarbazide-sensitive amine oxidase | VAP-1 | VAP1 | Vascular adhesion protein 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Membrane primary amine oxidase SINGLE PROTEIN Q16853

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000131471
Ensembl ENSG00000131471
GO Cellular Component GO:0005886 (plasma membrane)
GO:0009986 (cell surface)
GO:0016021 (integral to membrane)
GO Molecular Function GO:0005507 (copper ion binding)
GO:0008131 (primary amine oxidase activity)
GO:0042803 (protein homodimerization activity)
GO:0048038 (quinone binding)
GO:0052593 (tryptamine:oxygen oxidoreductase (deaminating) activity)
GO:0052594 (aminoacetone:oxygen oxidoreductase(deaminating) activity)
GO:0052595 (aliphatic-amine oxidase activity)
GO:0052596 (phenethylamine:oxygen oxidoreductase (deaminating) activity)
GO Biological Process GO:0006954 (inflammatory response)
GO:0007155 (cell adhesion)
GO:0009308 (amine metabolic process)
Wikipedia AOC3

Target Cross References - Protein

canSAR Q16853
Human Protein Atlas ENSG00000131471
PharmGKB PA24840
UniProt B2RCI5 Q16853 Q45F94

Target Cross References - Domain

InterPro IPR000269 (Cu_amine_oxidase.)
IPR015798 (Cu_amine_oxidase_C.)
IPR015800 (Cu_amine_oxidase_N2.)
IPR015801 (Cu_amine_oxidase_N2/3.)
IPR015802 (Cu_amine_oxidase_N3.)
IPR016182 (Cu_amine_oxidase_N-reg.)
Pfam PF01179 (Cu_amine_oxid)
PF02727 (Cu_amine_oxidN2)
PF02728 (Cu_amine_oxidN3)

Target Cross References - Structure

PDBe 1PU4 1US1 2C10 2C11 3ALA
CREDO 1PU4 1US1 2C10 2C11 3ALA