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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3419
Target Type SINGLE PROTEIN
Preferred Name Carboxypeptidase B2 isoform A
Synonyms CPB2 | CPU | Carboxypeptidase B2 | Carboxypeptidase U | Plasma carboxypeptidase B | TAFI | Thrombin-activable fibrinolysis inhibitor | pCPB
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > metallo protease > metallo protease mc clan > metallo protease m14a subfamily

Target Components

Component Description Relationship Accession
Carboxypeptidase B2 SINGLE PROTEIN Q96IY4

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000080618
Ensembl ENSG00000080618
GO Cellular Component GO:0005615 (extracellular space)
GO:0005623 (cell)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0004181 (metallocarboxypeptidase activity)
GO:0008270 (zinc ion binding)
GO Biological Process GO:0003331 (positive regulation of extracellular matrix constituent secretion)
GO:0006508 (proteolysis)
GO:0007596 (blood coagulation)
GO:0009408 (response to heat)
GO:0010757 (negative regulation of plasminogen activation)
GO:0042493 (response to drug)
GO:0042730 (fibrinolysis)
GO:0051918 (negative regulation of fibrinolysis)
GO:0071333 (cellular response to glucose stimulus)
GO:0097421 (liver regeneration)
GO:2000346 (negative regulation of hepatocyte proliferation)
Wikipedia Carboxypeptidase_B2

Target Cross References - Protein

Human Protein Atlas ENSG00000080618
IntAct Q96IY4
PharmGKB PA26822
UniProt A8K464 Q15114 Q5T9K1 Q5T9K2 Q96IY4 Q9P2Y6

Target Cross References - Domain

InterPro IPR000834 (Peptidase_M14.)
IPR003146 (Prot_inh_M14A.)
IPR009020 (Prot_inh_propept.)
Pfam PF00246 (Peptidase_M14)
PF02244 (Propep_M14)

Target Cross References - Structure

PDBe 3D66 3D67 3D68 3LMS 4P10
CREDO 3D66 3D67 3D68 3LMS 4P10
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