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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3418
Preferred Name Nicastrin
Synonyms KIAA0253 | NCSTN | Nicastrin
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > aspartic protease > aspartic protease ad clan > aspartic protease a22a subfamily > aspartic protease a22a regulatory subfamily

Target Components

Component Description Relationship Accession
Nicastrin SINGLE PROTEIN Q92542

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2094135 Gamma-secretase PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000162736
Ensembl ENSG00000162736
GO Cellular Component GO:0005765 (lysosomal membrane)
GO:0005783 (endoplasmic reticulum)
GO:0005794 (Golgi apparatus)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0005925 (focal adhesion)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0042470 (melanosome)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0004175 (endopeptidase activity)
GO:0005515 (protein binding)
GO:0008233 (peptidase activity)
GO Biological Process GO:0002262 (myeloid cell homeostasis)
GO:0006508 (proteolysis)
GO:0006509 (membrane protein ectodomain proteolysis)
GO:0007219 (Notch signaling pathway)
GO:0007220 (Notch receptor processing)
GO:0016485 (protein processing)
GO:0031293 (membrane protein intracellular domain proteolysis)
GO:0042098 (T cell proliferation)
GO:0042987 (amyloid precursor protein catabolic process)
GO:0043065 (positive regulation of apoptotic process)
GO:0043085 (positive regulation of catalytic activity)
GO:0048013 (ephrin receptor signaling pathway)
GO:0050435 (beta-amyloid metabolic process)
GO:0050673 (epithelial cell proliferation)
Wikipedia Nicastrin

Target Cross References - Protein

canSAR Q92542
CGD Acne inversa, familial 1
Human Protein Atlas ENSG00000162736
IntAct Q92542
Open Targets ENSG00000162736
PharmGKB PA142671271
Reactome R-HSA-1251985 (Nuclear signaling by ERBB4.)
R-HSA-1474228 (Degradation of the extracellular matrix.)
R-HSA-193692 (Regulated proteolysis of p75NTR.)
R-HSA-1980148 (Signaling by NOTCH3.)
R-HSA-1980150 (Signaling by NOTCH4.)
R-HSA-205043 (NRIF signals cell death from the nucleus.)
R-HSA-2122948 (Activated NOTCH1 Transmits Signal to the Nucleus.)
R-HSA-2644606 (Constitutive Signaling by NOTCH1 PEST Domain Mutants.)
R-HSA-2894862 (Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.)
R-HSA-2979096 (NOTCH2 Activation and Transmission of Signal to the Nucleus.)
R-HSA-3928665 (EPH-ephrin mediated repulsion of cells.)
R-HSA-6798695 (Neutrophil degranulation.)
UniProt Q5T207 Q5T208 Q86VV5 Q92542

Target Cross References - Domain

InterPro IPR008710 (Nicastrin.)
Pfam PF05450 (Nicastrin)