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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3418
Preferred Name Nicastrin
Synonyms KIAA0253 | NCSTN | Nicastrin
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > aspartic protease > aspartic protease ad clan > aspartic protease a22a subfamily > aspartic protease a22a regulatory subfamily

Target Components

Component Description Relationship Accession
Nicastrin SINGLE PROTEIN Q92542

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2094135 Gamma-secretase PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000162736
Ensembl ENSG00000162736
GO Cellular Component GO:0005783 (endoplasmic reticulum)
GO:0005794 (Golgi apparatus)
GO:0005887 (integral to plasma membrane)
GO:0042470 (melanosome)
GO Molecular Function GO:0005515 (protein binding)
GO Biological Process GO:0006509 (membrane protein ectodomain proteolysis)
GO:0006915 (apoptosis)
GO:0007219 (Notch signaling pathway)
GO:0007220 (Notch receptor processing)
GO:0008624 (induction of apoptosis by extracellular signals)
GO:0016485 (protein processing)
GO:0031293 (membrane protein intracellular domain proteolysis)
GO:0042987 (amyloid precursor protein catabolic process)
GO:0043085 (positive regulation of catalytic activity)
GO:0048011 (nerve growth factor receptor signaling pathway)
Wikipedia Nicastrin

Target Cross References - Protein

canSAR Q92542
CGD Acne inversa, familial 1
Human Protein Atlas ENSG00000162736
IntAct Q92542
PharmGKB PA142671271
Reactome REACT_11061 (Signalling by NGF.)
REACT_299 (Signaling by Notch.)
UniProt Q5T207 Q86VV5 Q92542

Target Cross References - Domain

InterPro IPR008710 (Nicastrin.)
Pfam PF05450 (Nicastrin)