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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3411
Preferred Name Prenyl protein specific protease
Synonyms CAAX prenyl protease 2 | FACE-2 | FACE2 | Farnesylated proteins-converting enzyme 2 | Prenyl protein-specific endoprotease 2 | RCE1 homolog | RCE1 | RCE1A | RCE1B | hRCE1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > protease unclassified > protease unclassified u family > protease unclassified u48 family

Target Components

Component Description Relationship Accession
CAAX prenyl protease 2 SINGLE PROTEIN Q9Y256

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000173653
Ensembl ENSG00000173653
GO Cellular Component GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030176 (integral component of endoplasmic reticulum membrane)
GO Molecular Function GO:0004175 (endopeptidase activity)
GO:0004197 (cysteine-type endopeptidase activity)
GO:0004222 (metalloendopeptidase activity)
GO:0008233 (peptidase activity)
GO:0016787 (hydrolase activity)
GO Biological Process GO:0006508 (proteolysis)
GO:0071586 (CAAX-box protein processing)
Wikipedia RCE1

Target Cross References - Protein

canSAR Q9Y256
Human Protein Atlas ENSG00000173653
IntAct Q9Y256
Guide to Pharmacology 2412
Open Targets ENSG00000173653
PharmGKB PA34302
Reactome R-HSA-5689880 (Ub-specific processing proteases.)
UniProt Q52LZ9 Q9Y256

Target Cross References - Domain

InterPro IPR003675 (CAAX_protease.)
Pfam PF02517 (Abi)