ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL3409
Target Type SINGLE PROTEIN
Preferred Name Glutathione S-transferase A1
Synonyms GST HA subunit 1 | GST class-alpha member 1 | GST-epsilon | GSTA1 | GSTA1-1 | GTH1 | Glutathione S-transferase A1 | Glutathione S-transferase A1, N-terminally processed
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Glutathione S-transferase A1 SINGLE PROTEIN P08263

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000243955
Ensembl ENSG00000243955
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0004364 (glutathione transferase activity)
GO:0016740 (transferase activity)
GO Biological Process GO:0006749 (glutathione metabolic process)
GO:0008152 (metabolic process)
GO:0030855 (epithelial cell differentiation)
GO:1901687 (glutathione derivative biosynthetic process)
Wikipedia Glutathione_S-transferase_A1

Target Cross References - Protein

canSAR P08263
Human Protein Atlas ENSG00000243955
IntAct P08263
Open Targets ENSG00000243955
PharmGKB PA29016
Reactome R-HSA-156590 (Glutathione conjugation.)
UniProt P08263 Q14750 Q5GHF8 Q5SZC1

Target Cross References - Domain

InterPro IPR003080 (GST_alpha.)
IPR004045 (Glutathione_S-Trfase_N.)
IPR004046 (GST_C.)
IPR010987 (Glutathione-S-Trfase_C-like.)
IPR012336 (Thioredoxin-like_fold.)
Pfam PF00043 (GST_C)
PF02798 (GST_N)

Target Cross References - Structure

PDBe 1GSD 1GSE 1GSF 1GUH 1K3L 1K3O 1K3Y 1LBK 1PKW 1PKZ 1PL1 1PL2 1USB 1XWG 1YDK 2R3X 2R6K 3I69 3I6A 3IK9 3KTL 3L0H 3Q74 3U6V More...
CREDO 1GSD 1GSE 1GSF 1GUH 1K3L 1K3O 1K3Y 1LBK 1PKW 1PKZ 1PL1 1PL2 1USB 1XWG 1YDK 2R3X 2R6K 3I69 3I6A 3IK9 3KTL 3L0H 3Q74 3U6V More...
spacer
spacer