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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3401
Target Type SINGLE PROTEIN
Preferred Name Pregnane X receptor
Synonyms NR1I2 | Nuclear receptor subfamily 1 group I member 2 | Orphan nuclear receptor PAR1 | Orphan nuclear receptor PXR | PXR | Pregnane X receptor | SXR | Steroid and xenobiotic receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transcription factor > nuclear receptor > nuclear hormone receptor subfamily 1 > nuclear hormone receptor subfamily 1 group i > nuclear hormone receptor subfamily 1 group i member 2

Target Components

Component Description Relationship Accession
Nuclear receptor subfamily 1 group I member 2 SINGLE PROTEIN O75469

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000144852
Ensembl ENSG00000144852
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0016604 (nuclear body)
GO:0045111 (intermediate filament cytoskeleton)
GO Molecular Function GO:0000977 (RNA polymerase II regulatory region sequence-specific DNA binding)
GO:0000981 (RNA polymerase II transcription factor activity, sequence-specific DNA binding)
GO:0001228 (transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding)
GO:0003677 (DNA binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0003707 (steroid hormone receptor activity)
GO:0003713 (transcription coactivator activity)
GO:0004879 (RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding)
GO:0005515 (protein binding)
GO:0008144 (drug binding)
GO:0008270 (zinc ion binding)
GO:0043565 (sequence-specific DNA binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006367 (transcription initiation from RNA polymerase II promoter)
GO:0006805 (xenobiotic metabolic process)
GO:0007165 (signal transduction)
GO:0008202 (steroid metabolic process)
GO:0010628 (positive regulation of gene expression)
GO:0030522 (intracellular receptor signaling pathway)
GO:0042738 (exogenous drug catabolic process)
GO:0042908 (xenobiotic transport)
GO:0043401 (steroid hormone mediated signaling pathway)
GO:0045892 (negative regulation of transcription, DNA-templated)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0046618 (drug export)
Wikipedia Pregnane_X_receptor

Target Cross References - Protein

canSAR O75469
Human Protein Atlas ENSG00000144852
IntAct O75469
Guide to Pharmacology 606
Open Targets ENSG00000144852
PharmGKB PA378
Pharos O75469 (Tchem)
Reactome R-HSA-383280 (Nuclear Receptor transcription pathway.)
UniProt O75469 Q006P5 Q008C8 Q96AC7 Q9UJ22 Q9UJ23 Q9UJ24 Q9UJ25 Q9UJ26 Q9UJ27 Q9UNW4

Target Cross References - Domain

InterPro IPR000536 (Nucl_hrmn_rcpt_lig-bd.)
IPR001628 (Znf_hrmn_rcpt.)
IPR001723 (Nuclear_hrmn_rcpt.)
IPR013088 (Znf_NHR/GATA.)
IPR035500 (NHR_like_dom_sf.)
Pfam PF00104 (Hormone_recep)
PF00105 (zf-C4)

Target Cross References - Structure

PDBe 1ILG 1ILH 1M13 1NRL 1SKX 2O9I 2QNV 3CTB 3HVL 3R8D 4J5W 4J5X 4NY9 4S0S 4S0T 4X1F 4X1G 4XAO 4XHD 5A86 5X0R 6BNS
CREDO 1ILG 1ILH 1M13 1NRL 1SKX 2O9I 2QNV 3CTB 3HVL 3R8D 4J5W 4J5X 4NY9 4S0S 4S0T 4X1F 4X1G 4XAO 4XHD 5A86 5X0R 6BNS
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