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Target Report Card

Target Name and Classification

Target ID CHEMBL3397
Preferred Name Cytochrome P450 2C9
Synonyms (R)-limonene 6-monooxygenase | (S)-limonene 6-monooxygenase | (S)-limonene 7-monooxygenase | CYP2C10 | CYP2C9 | CYPIIC9 | Cholesterol 25-hydroxylase | Cytochrome P-450MP | Cytochrome P450 2C9 | Cytochrome P450 MP-4 | Cytochrome P450 MP-8 | Cytochrome P450 PB-1 | S-mephenytoin 4-hydroxylase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > cytochrome p450 > cytochrome p450 family 2 > cytochrome p450 family 2c > cytochrome p450 2c9

Target Components

Component Description Relationship Accession
Cytochrome P450 2C9 SINGLE PROTEIN P11712

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000138109
Ensembl ENSG00000138109
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005792 (microsome)
GO:0043231 (intracellular membrane-bounded organelle)
GO Molecular Function GO:0004497 (monooxygenase activity)
GO:0005506 (iron ion binding)
GO:0008144 (drug binding)
GO:0008392 (arachidonic acid epoxygenase activity)
GO:0008395 (steroid hydroxylase activity)
GO:0009055 (electron carrier activity)
GO:0016491 (oxidoreductase activity)
GO:0016712 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen)
GO:0018675 ((S)-limonene 6-monooxygenase activity)
GO:0018676 ((S)-limonene 7-monooxygenase activity)
GO:0019825 (oxygen binding)
GO:0020037 (heme binding)
GO:0033767 (4-hydroxyacetophenone monooxygenase activity)
GO:0034875 (caffeine oxidase activity)
GO:0052741 ((R)-limonene 6-monooxygenase activity)
GO:0070330 (aromatase activity)
GO Biological Process GO:0006805 (xenobiotic metabolic process)
GO:0008202 (steroid metabolic process)
GO:0016098 (monoterpenoid metabolic process)
GO:0017144 (drug metabolic process)
GO:0019369 (arachidonic acid metabolic process)
GO:0019373 (epoxygenase P450 pathway)
GO:0019627 (urea metabolic process)
GO:0032787 (monocarboxylic acid metabolic process)
GO:0042737 (drug catabolic process)
GO:0042738 (exogenous drug catabolic process)
GO:0043603 (cellular amide metabolic process)
GO:0044281 (small molecule metabolic process)
GO:0055114 (oxidation-reduction process)
GO:0070989 (oxidative demethylation)
GO:0097267 (omega-hydroxylase P450 pathway)
Wikipedia CYP2C9

Target Cross References - Protein

canSAR P11712
CGD Drug metabolism, CYP2C9-related
Human Protein Atlas ENSG00000138109
IntAct P11712
PharmGKB PA126
UniProt P11712 P11713 Q16756 Q16872

Target Cross References - Domain

InterPro IPR001128 (Cyt_P450.)
IPR002401 (Cyt_P450_E_grp-I.)
IPR017972 (Cyt_P450_CS.)
Pfam PF00067 (p450)

Target Cross References - Structure

PDBe 1OG2 1OG5 1R9O 4NZ2