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Target Report Card

Target Name and Classification

Target ID CHEMBL3397
Preferred Name Cytochrome P450 2C9
Synonyms (R)-limonene 6-monooxygenase | (S)-limonene 6-monooxygenase | (S)-limonene 7-monooxygenase | CYP2C10 | CYP2C9 | CYPIIC9 | Cholesterol 25-hydroxylase | Cytochrome P-450MP | Cytochrome P450 2C9 | Cytochrome P450 MP-4 | Cytochrome P450 MP-8 | Cytochrome P450 PB-1 | S-mephenytoin 4-hydroxylase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > cytochrome p450 > cytochrome p450 family 2 > cytochrome p450 family 2c > cytochrome p450 2c9

Target Components

Component Description Relationship Accession
Cytochrome P450 2C9 SINGLE PROTEIN P11712

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000138109
Ensembl ENSG00000138109
GO Cellular Component GO:0043231 (intracellular membrane-bounded organelle)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005737 (cytoplasm)
GO Molecular Function GO:0008144 (drug binding)
GO:0018676 ((S)-limonene 7-monooxygenase activity)
GO:0034875 (caffeine oxidase activity)
GO:0004497 (monooxygenase activity)
GO:0005506 (iron ion binding)
GO:0016712 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen)
GO:0008395 (steroid hydroxylase activity)
GO:0016491 (oxidoreductase activity)
GO:0070330 (aromatase activity)
GO:0008392 (arachidonic acid epoxygenase activity)
GO:0018675 ((S)-limonene 6-monooxygenase activity)
GO:0019825 (oxygen binding)
GO:0020037 (heme binding)
GO:0052741 ((R)-limonene 6-monooxygenase activity)
GO Biological Process GO:0043603 (cellular amide metabolic process)
GO:0008202 (steroid metabolic process)
GO:0019369 (arachidonic acid metabolic process)
GO:0044281 (small molecule metabolic process)
GO:0006805 (xenobiotic metabolic process)
GO:0017144 (drug metabolic process)
GO:0097267 (omega-hydroxylase P450 pathway)
GO:0019627 (urea metabolic process)
GO:0019373 (epoxygenase P450 pathway)
GO:0032787 (monocarboxylic acid metabolic process)
GO:0042737 (drug catabolic process)
GO:0070989 (oxidative demethylation)
GO:0016098 (monoterpenoid metabolic process)
GO:0042738 (exogenous drug catabolic process)
GO:0055114 (oxidation-reduction process)
Wikipedia CYP2C9

Target Cross References - Protein

canSAR P11712
CGD Drug metabolism, CYP2C9-related
Human Protein Atlas ENSG00000138109
IntAct P11712
Guide to Pharmacology 1326 (CYP2C9)
PharmGKB PA126
UniProt P11713 P11712 Q16872 Q16756

Target Cross References - Domain

InterPro IPR002401 (Cyt_P450_E_grp-I.)
IPR017972 (Cyt_P450_CS.)
IPR001128 (Cyt_P450.)
Pfam PF00067 (p450)

Target Cross References - Structure

PDBe 1OG5 4NZ2 1OG2 1R9O