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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3397
Target Type SINGLE PROTEIN
Preferred Name Cytochrome P450 2C9
Synonyms (R)-limonene 6-monooxygenase | (S)-limonene 6-monooxygenase | (S)-limonene 7-monooxygenase | CYP2C10 | CYP2C9 | CYPIIC9 | Cytochrome P-450MP | Cytochrome P450 2C9 | Cytochrome P450 MP-4 | Cytochrome P450 MP-8 | Cytochrome P450 PB-1 | S-mephenytoin 4-hydroxylase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > cytochrome p450 > cytochrome p450 family 2 > cytochrome p450 family 2c > cytochrome p450 2c9

Target Components

Component Description Relationship Accession
Cytochrome P450 2C9 SINGLE PROTEIN P11712

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000138109
Ensembl ENSG00000138109
GO Cellular Component GO:0005789 (endoplasmic reticulum membrane)
GO:0005792 (microsome)
GO Molecular Function GO:0008144 (drug binding)
GO:0008395 (steroid hydroxylase activity)
GO:0009055 (electron carrier activity)
GO:0018675 ((S)-limonene 6-monooxygenase activity)
GO:0018676 ((S)-limonene 7-monooxygenase activity)
GO:0019825 (oxygen binding)
GO:0020037 (heme binding)
GO:0033767 (4-hydroxyacetophenone monooxygenase activity)
GO:0034875 (caffeine oxidase activity)
GO Biological Process GO:0006805 (xenobiotic metabolic process)
GO:0008202 (steroid metabolic process)
GO:0016098 (monoterpenoid metabolic process)
GO:0019627 (urea metabolic process)
GO:0032787 (monocarboxylic acid metabolic process)
GO:0042738 (exogenous drug catabolic process)
GO:0070989 (oxidative demethylation)
Wikipedia CYP2C9

Target Cross References - Protein

canSAR P11712
CGD Drug metabolism, CYP2C9-related
Human Protein Atlas ENSG00000138109
IntAct P11712
Guide to Pharmacology 1326 (CYP2C9)
PharmGKB PA126
Reactome REACT_13433 (Biological oxidations.)
UniProt P11712 P11713 Q16756 Q16872

Target Cross References - Domain

InterPro IPR001128 (Cyt_P450.)
IPR002401 (Cyt_P450_E_grp-I.)
IPR017972 (Cyt_P450_CS.)
Pfam PF00067 (p450)

Target Cross References - Structure

PDBe 1OG2 1OG5 1R9O
CREDO 1OG2 1OG5 1R9O
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