ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL3396
Target Type SINGLE PROTEIN
Preferred Name DNA topoisomerase II beta
Synonyms DNA topoisomerase 2-beta | DNA topoisomerase II, beta isozyme | TOP2B
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > isomerase

Target Components

Component Description Relationship Accession
DNA topoisomerase 2-beta SINGLE PROTEIN Q02880

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2094255 DNA topoisomerase II PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000077097
Ensembl ENSG00000077097
GO Cellular Component GO:0000792 (heterochromatin)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005730 (nucleolus)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:1990904 (ribonucleoprotein complex)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0003677 (DNA binding)
GO:0003682 (chromatin binding)
GO:0003916 (DNA topoisomerase activity)
GO:0003918 (DNA topoisomerase type II (ATP-hydrolyzing) activity)
GO:0005080 (protein kinase C binding)
GO:0005524 (ATP binding)
GO:0008022 (protein C-terminus binding)
GO:0016853 (isomerase activity)
GO:0019899 (enzyme binding)
GO:0042826 (histone deacetylase binding)
GO:0043021 (ribonucleoprotein complex binding)
GO:0046872 (metal ion binding)
GO:0046982 (protein heterodimerization activity)
GO:0061505 (DNA topoisomerase II activity)
GO Biological Process GO:0000712 (resolution of meiotic recombination intermediates)
GO:0000819 (sister chromatid segregation)
GO:0001764 (neuron migration)
GO:0006259 (DNA metabolic process)
GO:0006265 (DNA topological change)
GO:0007409 (axonogenesis)
GO:0016925 (protein sumoylation)
GO:0030900 (forebrain development)
GO:0044774 (mitotic DNA integrity checkpoint)
Wikipedia TOP2B

Target Cross References - Protein

canSAR Q02880
Human Protein Atlas ENSG00000077097
IntAct Q02880
Open Targets ENSG00000077097
PharmGKB PA36672
Reactome R-HSA-4615885 (SUMOylation of DNA replication proteins.)
UniProt Q02880 Q13600 Q9UMG8 Q9UQP8

Target Cross References - Domain

InterPro IPR001241 (Topo_IIA.)
IPR002205 (Topo_IIA_A/C.)
IPR003594 (HATPase_C.)
IPR006171 (TOPRIM_domain.)
IPR012542 (DTHCT.)
IPR013506 (Topo_IIA_bsu_dom2.)
IPR013757 (Topo_IIA_A_a_sf.)
IPR013758 (Topo_IIA_A/C_ab.)
IPR013759 (Topo_IIA_B_C.)
IPR013760 (Topo_IIA-like_dom_sf.)
IPR014721 (Ribosomal_S5_D2-typ_fold_subgr.)
IPR018522 (TopoIIA_CS.)
IPR020568 (Ribosomal_S5_D2-typ_fold.)
IPR031660 (TOPRIM_C.)
IPR034157 (TOPRIM_TopoII.)
IPR036890 (HATPase_C_sf.)
Pfam PF00204 (DNA_gyraseB)
PF00521 (DNA_topoisoIV)
PF01751 (Toprim)
PF02518 (HATPase_c)
PF08070 (DTHCT)
PF16898 (TOPRIM_C)

Target Cross References - Structure

PDBe 3QX3 4G0U 4G0V 4G0W 4J3N 5GWI 5GWJ
CREDO 3QX3 4G0U 4G0V 4G0W 4J3N 5GWI 5GWJ
spacer
spacer