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Target Report Card

Target Name and Classification

Target ID CHEMBL3385
Target Type SINGLE PROTEIN
Preferred Name MAP kinase ERK1
Synonyms ERK-1 | ERK1 | ERT2 | Extracellular signal-regulated kinase 1 | Insulin-stimulated MAP2 kinase | MAP kinase 3 | MAP kinase isoform p44 | MAPK 3 | MAPK3 | Microtubule-associated protein 2 kinase | Mitogen-activated protein kinase 3 | PRKM3 | p44-ERK1 | p44-MAPK
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > cmgc protein kinase group > cmgc protein kinase mapk family > cmgc protein kinase erk subfamily

Target Components

Component Description Relationship Accession
Mitogen-activated protein kinase 3 SINGLE PROTEIN P27361

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL1907606 Mitogen-activated protein kinase; ERK1/ERK2 PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL3545022 Ulixertinib MAP kinase ERK1 inhibitor 2 DOI Other
CHEMBL3544964 GDC-0994 MAP kinase ERK1 inhibitor 1 Other
CHEMBL3545001 MK-8353 MAP kinase ERK1 inhibitor 1 Other

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000102882
Ensembl ENSG00000102882
GO Cellular Component GO:0005634 (nucleus)
GO:0005635 (nuclear envelope)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005769 (early endosome)
GO:0005770 (late endosome)
GO:0005794 (Golgi apparatus)
GO:0005829 (cytosol)
GO:0005856 (cytoskeleton)
GO:0005901 (caveola)
GO:0005925 (focal adhesion)
GO:0015630 (microtubule cytoskeleton)
GO:0031143 (pseudopodium)
GO:0043234 (protein complex)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0001784 (phosphotyrosine binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004707 (MAP kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0019902 (phosphatase binding)
GO:0097110 (scaffold protein binding)
GO Biological Process GO:0000165 (MAPK cascade)
GO:0000187 (activation of MAPK activity)
GO:0000189 (MAPK import into nucleus)
GO:0001934 (positive regulation of protein phosphorylation)
GO:0006351 (transcription, DNA-templated)
GO:0006361 (transcription initiation from RNA polymerase I promoter)
GO:0006461 (protein complex assembly)
GO:0006468 (protein phosphorylation)
GO:0006915 (apoptotic process)
GO:0006974 (cellular response to DNA damage stimulus)
GO:0006975 (DNA damage induced protein phosphorylation)
GO:0007049 (cell cycle)
GO:0007411 (axon guidance)
GO:0008543 (fibroblast growth factor receptor signaling pathway)
GO:0009636 (response to toxic substance)
GO:0009887 (organ morphogenesis)
GO:0014032 (neural crest cell development)
GO:0014066 (regulation of phosphatidylinositol 3-kinase signaling)
GO:0016032 (viral process)
GO:0016310 (phosphorylation)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0019233 (sensory perception of pain)
GO:0019369 (arachidonic acid metabolic process)
GO:0030168 (platelet activation)
GO:0030509 (BMP signaling pathway)
GO:0030878 (thyroid gland development)
GO:0031281 (positive regulation of cyclase activity)
GO:0031663 (lipopolysaccharide-mediated signaling pathway)
GO:0032212 (positive regulation of telomere maintenance via telomerase)
GO:0032496 (response to lipopolysaccharide)
GO:0032872 (regulation of stress-activated MAPK cascade)
GO:0033129 (positive regulation of histone phosphorylation)
GO:0035066 (positive regulation of histone acetylation)
GO:0035556 (intracellular signal transduction)
GO:0038083 (peptidyl-tyrosine autophosphorylation)
GO:0038095 (Fc-epsilon receptor signaling pathway)
GO:0038096 (Fc-gamma receptor signaling pathway involved in phagocytosis)
GO:0042473 (outer ear morphogenesis)
GO:0043330 (response to exogenous dsRNA)
GO:0045727 (positive regulation of translation)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0048538 (thymus development)
GO:0051090 (regulation of sequence-specific DNA binding transcription factor activity)
GO:0051216 (cartilage development)
GO:0051493 (regulation of cytoskeleton organization)
GO:0051973 (positive regulation of telomerase activity)
GO:0060020 (Bergmann glial cell differentiation)
GO:0060324 (face development)
GO:0060397 (JAK-STAT cascade involved in growth hormone signaling pathway)
GO:0060425 (lung morphogenesis)
GO:0060440 (trachea formation)
GO:0061308 (cardiac neural crest cell development involved in heart development)
GO:0070371 (ERK1 and ERK2 cascade)
GO:0070374 (positive regulation of ERK1 and ERK2 cascade)
GO:0070498 (interleukin-1-mediated signaling pathway)
GO:0070849 (response to epidermal growth factor)
GO:0071260 (cellular response to mechanical stimulus)
GO:0072584 (caveolin-mediated endocytosis)
GO:0090170 (regulation of Golgi inheritance)
GO:1900034 (regulation of cellular response to heat)
GO:1904355 (positive regulation of telomere capping)
GO:1904417 (positive regulation of xenophagy)
GO:2000641 (regulation of early endosome to late endosome transport)
GO:2000657 (negative regulation of apolipoprotein binding)
Wikipedia MAPK3

Target Cross References - Protein

canSAR P27361
Human Protein Atlas ENSG00000102882
IntAct P27361
Guide to Pharmacology 1494
Open Targets ENSG00000102882
PharmGKB PA30622
Pharos P27361 (Tchem)
Reactome R-HSA-110056 (MAPK3 (ERK1) activation.)
R-HSA-112409 (RAF-independent MAPK1/3 activation.)
R-HSA-1169408 (ISG15 antiviral mechanism.)
R-HSA-1295596 (Spry regulation of FGF signaling.)
R-HSA-162658 (Golgi Cisternae Pericentriolar Stack Reorganization.)
R-HSA-198753 (ERK/MAPK targets.)
R-HSA-202670 (ERKs are inactivated.)
R-HSA-2029482 (Regulation of actin dynamics for phagocytic cup formation.)
R-HSA-2559580 (Oxidative Stress Induced Senescence.)
R-HSA-2559582 (Senescence-Associated Secretory Phenotype (SASP).)
R-HSA-2559585 (Oncogene Induced Senescence.)
R-HSA-2871796 (FCERI mediated MAPK activation.)
R-HSA-3371453 (Regulation of HSF1-mediated heat shock response.)
R-HSA-375165 (NCAM signaling for neurite out-growth.)
R-HSA-445144 (Signal transduction by L1.)
R-HSA-450341 (Activation of the AP-1 family of transcription factors.)
R-HSA-456926 (Thrombin signalling through proteinase activated receptors (PARs).)
R-HSA-5654726 (Negative regulation of FGFR1 signaling.)
R-HSA-5654727 (Negative regulation of FGFR2 signaling.)
R-HSA-5654732 (Negative regulation of FGFR3 signaling.)
R-HSA-5654733 (Negative regulation of FGFR4 signaling.)
R-HSA-5663213 (RHO GTPases Activate WASPs and WAVEs.)
R-HSA-5673001 (RAF/MAP kinase cascade.)
R-HSA-5674135 (MAP2K and MAPK activation.)
R-HSA-5674499 (Negative feedback regulation of MAPK pathway.)
R-HSA-5675221 (Negative regulation of MAPK pathway.)
R-HSA-6802946 (Signaling by moderate kinase activity BRAF mutants.)
R-HSA-6802948 (Signaling by high-kinase activity BRAF mutants.)
R-HSA-6802949 (Signaling by RAS mutants.)
R-HSA-6802952 (Signaling by BRAF and RAF fusions.)
R-HSA-6802955 (Paradoxical activation of RAF signaling by kinase inactive BRAF.)
R-HSA-6811558 (PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.)
R-HSA-73728 (RNA Polymerase I Promoter Opening.)
R-HSA-74749 (Signal attenuation.)
R-HSA-879415 (Advanced glycosylation endproduct receptor signaling.)
R-HSA-881907 (Gastrin-CREB signalling pathway via PKC and MAPK.)
R-HSA-982772 (Growth hormone receptor signaling.)
UniProt A8CZ58 B0LPG3 P27361 Q8NHX1

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR003527 (MAP_kinase_CS.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR008349 (MAPK_ERK1/2.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF00069 (Pkinase)

Target Cross References - Structure

PDBe 2ZOQ 4QTB
CREDO 2ZOQ 4QTB
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