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Target Report Card

Target Name and Classification

Target ID CHEMBL3381
Target Type SINGLE PROTEIN
Preferred Name Small conductance calcium-activated potassium channel protein 3
Synonyms K3 | KCNN3 | KCa2.3 | SK3 | SKCa 3 | SKCa3 | Small conductance calcium-activated potassium channel protein 3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > voltage-gated ion channel > potassium channels > calcium-activated potassium channel

Target Components

Component Description Relationship Accession
Small conductance calcium-activated potassium channel protein 3 SINGLE PROTEIN Q9UGI6

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000143603
Ensembl ENSG00000143603
GO Cellular Component GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0043025 (neuronal cell body)
GO Molecular Function GO:0005516 (calmodulin binding)
GO:0015269 (calcium-activated potassium channel activity)
GO:0016286 (small conductance calcium-activated potassium channel activity)
GO Biological Process GO:0006810 (transport)
GO:0006811 (ion transport)
GO:0006813 (potassium ion transport)
GO:0071805 (potassium ion transmembrane transport)
GO:1903955 (positive regulation of protein targeting to mitochondrion)
Wikipedia SK3

Target Cross References - Protein

canSAR Q9UGI6
Human Protein Atlas ENSG00000143603
Guide to Pharmacology 383
Open Targets ENSG00000143603
PharmGKB PA30072
Pharos Q9UGI6 (Tchem)
Reactome R-HSA-1296052 (Ca2+ activated K+ channels.)
UniProt B1ANX0 O43517 Q86VF9 Q8WXG7 Q9UGI6

Target Cross References - Domain

InterPro IPR004178 (CaM-bd_dom.)
IPR013099 (K_chnl_dom.)
IPR015449 (K_chnl_Ca-activ_SK.)
Pfam PF02888 (CaMBD)
PF03530 (SK_channel)
PF07885 (Ion_trans_2)
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