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Target Report Card

Target Name and Classification

Target ID CHEMBL3379
Preferred Name Cytochrome P450 4F2
Synonyms 20-HETE synthase | 20-hydroxyeicosatetraenoic acid synthase | Arachidonic acid omega-hydroxylase | CYP4F2 | CYPIVF2 | Cytochrome P450 4F2 | Cytochrome P450-LTB-omega | Leukotriene-B(4) 20-monooxygenase 1 | Leukotriene-B(4) omega-hydroxylase 1 | Phylloquinone omega-hydroxylase CYP4F2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > cytochrome p450 > cytochrome p450 family 4 > cytochrome p450 family 4f > cytochrome p450 4f2

Target Components

Component Description Relationship Accession
Phylloquinone omega-hydroxylase CYP4F2 SINGLE PROTEIN P78329

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000186115
Ensembl ENSG00000186115
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0016020 (membrane)
GO:0016324 (apical plasma membrane)
GO:0031090 (organelle membrane)
GO:0043231 (intracellular membrane-bounded organelle)
GO Molecular Function GO:0004497 (monooxygenase activity)
GO:0005506 (iron ion binding)
GO:0005515 (protein binding)
GO:0008392 (arachidonic acid epoxygenase activity)
GO:0016491 (oxidoreductase activity)
GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen)
GO:0016709 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen)
GO:0018685 (alkane 1-monooxygenase activity)
GO:0020037 (heme binding)
GO:0046872 (metal ion binding)
GO:0050051 (leukotriene-B4 20-monooxygenase activity)
GO:0052869 (arachidonic acid omega-hydroxylase activity)
GO:0052870 (tocopherol omega-hydroxylase activity)
GO:0052871 (alpha-tocopherol omega-hydroxylase activity)
GO:0052872 (tocotrienol omega-hydroxylase activity)
GO:0097258 (20-hydroxy-leukotriene B4 omega oxidase activity)
GO:0097259 (20-aldehyde-leukotriene B4 20-monooxygenase activity)
GO Biological Process GO:0000038 (very long-chain fatty acid metabolic process)
GO:0001676 (long-chain fatty acid metabolic process)
GO:0003091 (renal water homeostasis)
GO:0003095 (pressure natriuresis)
GO:0006690 (icosanoid metabolic process)
GO:0006691 (leukotriene metabolic process)
GO:0007596 (blood coagulation)
GO:0008217 (regulation of blood pressure)
GO:0017144 (drug metabolic process)
GO:0019369 (arachidonic acid metabolic process)
GO:0019373 (epoxygenase P450 pathway)
GO:0032304 (negative regulation of icosanoid secretion)
GO:0032305 (positive regulation of icosanoid secretion)
GO:0036101 (leukotriene B4 catabolic process)
GO:0042360 (vitamin E metabolic process)
GO:0042361 (menaquinone catabolic process)
GO:0042376 (phylloquinone catabolic process)
GO:0042377 (vitamin K catabolic process)
GO:0055078 (sodium ion homeostasis)
GO:0055114 (oxidation-reduction process)
GO:0097267 (omega-hydroxylase P450 pathway)
Wikipedia CYP4F2

Target Cross References - Protein

canSAR P78329
CGD Warfarin metabolism
Human Protein Atlas ENSG00000186115
IntAct P78329
Guide to Pharmacology 1344
Open Targets ENSG00000186115
PharmGKB PA27121
Reactome R-HSA-211935 (Fatty acids.)
R-HSA-211958 (Miscellaneous substrates.)
R-HSA-211979 (Eicosanoids.)
R-HSA-2142691 (Synthesis of Leukotrienes (LT) and Eoxins (EX).)
R-HSA-2142816 (Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).)
UniProt A0A024R7K3 A8K425 B4DV75 P78329 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8

Target Cross References - Domain

InterPro IPR001128 (Cyt_P450.)
IPR002401 (Cyt_P450_E_grp-I.)
IPR017972 (Cyt_P450_CS.)
IPR036396 (Cyt_P450_sf.)
Pfam PF00067 (p450)