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Target Report Card

Target Name and Classification

Target ID CHEMBL3378
Preferred Name Tumor necrosis factor receptor R1
Synonyms CD_antigen=CD120a | TBPI | TNF-R1 | TNF-RI | TNFAR | TNFR-I | TNFR1 | TNFRSF1A | Tumor necrosis factor receptor 1 | Tumor necrosis factor receptor superfamily member 1A | Tumor necrosis factor receptor superfamily member 1A, membrane form | Tumor necrosis factor receptor type I | Tumor necrosis factor-binding protein 1 | p55 | p60
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor

Target Components

Component Description Relationship Accession
Tumor necrosis factor receptor superfamily member 1A SINGLE PROTEIN P19438

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL2109590 GSK-1995057 Tumor necrosis factor receptor R1 inhibitor 1 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000067182
Ensembl ENSG00000067182
GO Cellular Component GO:0000139 (Golgi membrane)
GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005739 (mitochondrion)
GO:0005794 (Golgi apparatus)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0043235 (receptor complex)
GO:0045121 (membrane raft)
GO Molecular Function GO:0005031 (tumor necrosis factor-activated receptor activity)
GO:0005515 (protein binding)
GO:0042802 (identical protein binding)
GO:0043120 (tumor necrosis factor binding)
GO Biological Process GO:0006693 (prostaglandin metabolic process)
GO:0006915 (apoptotic process)
GO:0006952 (defense response)
GO:0006954 (inflammatory response)
GO:0006955 (immune response)
GO:0007165 (signal transduction)
GO:0007166 (cell surface receptor signaling pathway)
GO:0007249 (I-kappaB kinase/NF-kappaB signaling)
GO:0008625 (extrinsic apoptotic signaling pathway via death domain receptors)
GO:0008630 (intrinsic apoptotic signaling pathway in response to DNA damage)
GO:0010803 (regulation of tumor necrosis factor-mediated signaling pathway)
GO:0016032 (viral process)
GO:0019221 (cytokine-mediated signaling pathway)
GO:0032496 (response to lipopolysaccharide)
GO:0033209 (tumor necrosis factor-mediated signaling pathway)
GO:0042127 (regulation of cell proliferation)
GO:0042531 (positive regulation of tyrosine phosphorylation of STAT protein)
GO:0042742 (defense response to bacterium)
GO:0042981 (regulation of apoptotic process)
GO:0043123 (positive regulation of I-kappaB kinase/NF-kappaB signaling)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0050728 (negative regulation of inflammatory response)
GO:0050729 (positive regulation of inflammatory response)
GO:0071260 (cellular response to mechanical stimulus)
GO:0071550 (death-inducing signaling complex assembly)
GO:0072659 (protein localization to plasma membrane)
GO:1903140 (regulation of establishment of endothelial barrier)
GO:2000304 (positive regulation of ceramide biosynthetic process)
Wikipedia TNFRSF1A

Target Cross References - Protein

canSAR P19438
CGD Periodic fever, familial (TNF receptor-associated periodic syndrome)
Human Protein Atlas ENSG00000067182
IntAct P19438
Open Targets ENSG00000067182
PharmGKB PA36609
Reactome R-HSA-5357786 (TNFR1-induced proapoptotic signaling.)
R-HSA-5357905 (Regulation of TNFR1 signaling.)
R-HSA-5357956 (TNFR1-induced NFkappaB signaling pathway.)
R-HSA-5626978 (TNFR1-mediated ceramide production.)
R-HSA-5669034 (TNFs bind their physiological receptors.)
R-HSA-6783783 (Interleukin-10 signaling.)
R-HSA-75893 (TNF signaling.)
UniProt A8K4X3 B2RDE4 B3KPQ1 B4DQB7 B4E309 B5M0B5 D3DUR1 P19438 Q9UCA4

Target Cross References - Domain

InterPro IPR000488 (Death_domain.)
IPR001368 (TNFR/NGFR_Cys_rich_reg.)
IPR011029 (DEATH-like_dom_sf.)
IPR020419 (TNFR_1A.)
IPR033993 (TNFRSF1A_N.)
IPR033994 (TNFRSF1A_death.)
Pfam PF00020 (TNFR_c6)
PF00531 (Death)

Target Cross References - Structure