ChEMBL logo


ChEMBL Statistics
  Loading Statistics...

Target Report Card

Target Name and Classification

Target ID CHEMBL3359
Preferred Name Formyl peptide receptor 1
Synonyms FPR | FPR1 | N-formyl peptide receptor | N-formylpeptide chemoattractant receptor | fMLP receptor | fMet-Leu-Phe receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > peptide receptor (family a gpcr) > n-formyl methionyl peptide receptor > n-formyl methionyl peptide receptor

Target Components

Component Description Relationship Accession
fMet-Leu-Phe receptor SINGLE PROTEIN P21462

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3038479 fMet-Leu-Phe receptor 1/2 PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000171051
Ensembl ENSG00000171051
GO Cellular Component GO:0005768 (endosome)
GO:0005886 (plasma membrane)
GO:0016021 (integral to membrane)
GO Molecular Function GO:0004982 (N-formyl peptide receptor activity)
GO Biological Process GO:0000187 (activation of MAPK activity)
GO:0006928 (cellular component movement)
GO:0006935 (chemotaxis)
GO:0007188 (G-protein signaling, coupled to cAMP nucleotide second messenger)
GO:0007263 (nitric oxide mediated signal transduction)
Wikipedia Formyl_peptide_receptor_1

Target Cross References - Protein

canSAR P21462
Human Protein Atlas ENSG00000171051
IntAct P21462
Guide to Pharmacology 222 (FPR1)
PharmGKB PA28244
Reactome REACT_14797 (Signaling by GPCR.)
UniProt P21462 Q14939 Q7Z6A4 Q86U52 Q9NS48

Target Cross References - Domain

InterPro IPR000276 (7TM_GPCR_Rhodpsn.)
IPR000826 (Frt_met_rcpt.)
IPR017452 (GPCR_Rhodpsn_supfam.)
Pfam PF00001 (7tm_1)