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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL333
Target Type SINGLE PROTEIN
Preferred Name Matrix metalloproteinase-2
Synonyms 72 kDa gelatinase | 72 kDa type IV collagenase | CLG4A | Gelatinase A | MMP-2 | MMP2 | Matrix metalloproteinase-2 | PEX | TBE-1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > metallo protease > metallo protease mam clan > metallo protease m10a subfamily

Target Components

Component Description Relationship Accession
72 kDa type IV collagenase SINGLE PROTEIN P08253

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111321 Matrix metalloproteinase (2 and 3) SELECTIVITY GROUP
CHEMBL2095216 Collagenase PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000087245
Ensembl ENSG00000087245
GO Cellular Component GO:0005576 (extracellular region)
GO:0005578 (proteinaceous extracellular matrix)
GO:0005615 (extracellular space)
GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0030017 (sarcomere)
GO:0031012 (extracellular matrix)
GO Molecular Function GO:0004222 (metalloendopeptidase activity)
GO:0004252 (serine-type endopeptidase activity)
GO:0005515 (protein binding)
GO:0008233 (peptidase activity)
GO:0008237 (metallopeptidase activity)
GO:0008270 (zinc ion binding)
GO:0016787 (hydrolase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0001525 (angiogenesis)
GO:0001666 (response to hypoxia)
GO:0001955 (blood vessel maturation)
GO:0001957 (intramembranous ossification)
GO:0006508 (proteolysis)
GO:0007566 (embryo implantation)
GO:0022617 (extracellular matrix disassembly)
GO:0030574 (collagen catabolic process)
GO:0035987 (endodermal cell differentiation)
GO:0044267 (cellular protein metabolic process)
GO:0045089 (positive regulation of innate immune response)
GO:0048013 (ephrin receptor signaling pathway)
GO:0048705 (skeletal system morphogenesis)
GO:0060325 (face morphogenesis)
GO:0060346 (bone trabecula formation)
GO:0071230 (cellular response to amino acid stimulus)
Wikipedia MMP2

Target Cross References - Protein

canSAR P08253
CGD Torg-Winchester syndrome; Nodulosis-arthropathy-osteolysis
Human Protein Atlas ENSG00000087245
IntAct P08253
Guide to Pharmacology 1629
MICAD NBK23317 (Matrix metalloproteinase 2 (MMP2) receptor)
Open Targets ENSG00000087245
PharmGKB PA30877
Reactome R-HSA-1442490 (Collagen degradation.)
R-HSA-1474228 (Degradation of the extracellular matrix.)
R-HSA-1592389 (Activation of Matrix Metalloproteinases.)
R-HSA-381426 (Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).)
R-HSA-3928665 (EPH-ephrin mediated repulsion of cells.)
R-HSA-6785807 (Interleukin-4 and 13 signaling.)
UniProt B2R6U1 B4DWH3 E9PE45 P08253 Q9UCJ8

Target Cross References - Domain

InterPro IPR000562 (FN_type2_col-bd.)
IPR000585 (Hemopexin-like_dom.)
IPR001818 (Pept_M10_metallopeptidase.)
IPR002477 (Peptidoglycan-bd-like.)
IPR006026 (Peptidase_Metallo.)
IPR013806 (Kringle-like.)
IPR018486 (Hemopexin_CS.)
IPR018487 (Hemopexin-like_repeat.)
IPR021158 (Pept_M10A_Zn_BS.)
IPR021190 (Pept_M10A.)
IPR024079 (MetalloPept_cat_dom.)
IPR028708 (72kDa_collagenase.)
IPR033739 (M10A_MMP.)
Pfam PF00040 (fn2)
PF00045 (Hemopexin)
PF00413 (Peptidase_M10)
PF01471 (PG_binding_1)

Target Cross References - Structure

PDBe 1CK7 1EAK 1GEN 1GXD 1QIB 1RTG 3AYU
CREDO 1CK7 1EAK 1GEN 1GXD 1QIB 1RTG 3AYU
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