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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL332
Target Type SINGLE PROTEIN
Preferred Name Matrix metalloproteinase-1
Synonyms 22 kDa interstitial collagenase | 27 kDa interstitial collagenase | CLG | Fibroblast collagenase | Interstitial collagenase | MMP-1 | MMP1 | Matrix metalloproteinase-1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > metallo protease > metallo protease mam clan > metallo protease m10a subfamily

Target Components

Component Description Relationship Accession
Interstitial collagenase SINGLE PROTEIN P03956

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111422 Matrix metalloproteinase (1 and 13) SELECTIVITY GROUP
CHEMBL2095216 Collagenase PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1200567 DOXYCYCLINE HYCLATE Matrix metalloproteinase-1 inhibitor 4 DailyMed PubMed PubMed PubMed
CHEMBL1200699 DOXYCYCLINE HYDRATE Matrix metalloproteinase-1 inhibitor 4 DailyMed PubMed PubMed PubMed
CHEMBL2364574 DOXYCYCLINE CALCIUM Matrix metalloproteinase-1 inhibitor 4 DailyMed PubMed PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000196611
Ensembl ENSG00000196611
GO Cellular Component GO:0005576 (extracellular region)
GO:0005578 (proteinaceous extracellular matrix)
GO:0031012 (extracellular matrix)
GO Molecular Function GO:0004175 (endopeptidase activity)
GO:0004222 (metalloendopeptidase activity)
GO:0004252 (serine-type endopeptidase activity)
GO:0005509 (calcium ion binding)
GO:0008233 (peptidase activity)
GO:0008237 (metallopeptidase activity)
GO:0008270 (zinc ion binding)
GO:0016787 (hydrolase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006508 (proteolysis)
GO:0016032 (viral process)
GO:0022617 (extracellular matrix disassembly)
GO:0030574 (collagen catabolic process)
GO:0032461 (positive regulation of protein oligomerization)
GO:0044267 (cellular protein metabolic process)
GO:0050900 (leukocyte migration)
Wikipedia MMP1

Target Cross References - Protein

canSAR P03956
Human Protein Atlas ENSG00000196611
IntAct P03956
Guide to Pharmacology 1628
Open Targets ENSG00000196611
PharmGKB PA30867
Reactome R-HSA-1442490 (Collagen degradation.)
R-HSA-1474228 (Degradation of the extracellular matrix.)
R-HSA-1592389 (Activation of Matrix Metalloproteinases.)
R-HSA-210991 (Basigin interactions.)
R-HSA-381426 (Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).)
R-HSA-6785807 (Interleukin-4 and 13 signaling.)
UniProt P03956 P08156

Target Cross References - Domain

InterPro IPR000585 (Hemopexin-like_dom.)
IPR001818 (Pept_M10_metallopeptidase.)
IPR002477 (Peptidoglycan-bd-like.)
IPR006026 (Peptidase_Metallo.)
IPR016293 (Pept_M10A_stromelysin-type.)
IPR018486 (Hemopexin_CS.)
IPR018487 (Hemopexin-like_repeat.)
IPR021158 (Pept_M10A_Zn_BS.)
IPR021190 (Pept_M10A.)
IPR024079 (MetalloPept_cat_dom.)
IPR033739 (M10A_MMP.)
Pfam PF00045 (Hemopexin)
PF00413 (Peptidase_M10)
PF01471 (PG_binding_1)

Target Cross References - Structure

PDBe 1CGE 1CGF 1CGL 1HFC 1SU3 2CLT 2J0T 2TCL 3SHI 4AUO 966C
CREDO 1CGE 1CGF 1CGL 1HFC 1SU3 2CLT 2J0T 2TCL 3SHI 4AUO 966C
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