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Target Report Card

Target Name and Classification

Target ID CHEMBL3311
Preferred Name LDL receptor
Synonyms LDL receptor | LDLR | Low-density lipoprotein receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor

Target Components

Component Description Relationship Accession
Low-density lipoprotein receptor SINGLE PROTEIN P01130

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000130164
Ensembl ENSG00000130164
GO Cellular Component GO:0005615 (extracellular space)
GO:0005622 (intracellular)
GO:0005764 (lysosome)
GO:0005768 (endosome)
GO:0005769 (early endosome)
GO:0005770 (late endosome)
GO:0005794 (Golgi apparatus)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0005905 (clathrin-coated pit)
GO:0009897 (external side of plasma membrane)
GO:0009986 (cell surface)
GO:0010008 (endosome membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016323 (basolateral plasma membrane)
GO:0030669 (clathrin-coated endocytic vesicle membrane)
GO:0034362 (low-density lipoprotein particle)
GO:0036020 (endolysosome membrane)
GO:0036477 (somatodendritic compartment)
GO:0043235 (receptor complex)
GO:0045177 (apical part of cell)
GO:0097443 (sorting endosome)
GO:1990666 (PCSK9-LDLR complex)
GO Molecular Function GO:0001540 (beta-amyloid binding)
GO:0001618 (virus receptor activity)
GO:0002020 (protease binding)
GO:0005041 (low-density lipoprotein receptor activity)
GO:0005509 (calcium ion binding)
GO:0005515 (protein binding)
GO:0030169 (low-density lipoprotein particle binding)
GO:0030229 (very-low-density lipoprotein particle receptor activity)
GO:0032050 (clathrin heavy chain binding)
GO:0042802 (identical protein binding)
GO Biological Process GO:0006629 (lipid metabolic process)
GO:0006869 (lipid transport)
GO:0006897 (endocytosis)
GO:0006898 (receptor-mediated endocytosis)
GO:0007616 (long-term memory)
GO:0008202 (steroid metabolic process)
GO:0008203 (cholesterol metabolic process)
GO:0010628 (positive regulation of gene expression)
GO:0010629 (negative regulation of gene expression)
GO:0010867 (positive regulation of triglyceride biosynthetic process)
GO:0010899 (regulation of phosphatidylcholine catabolic process)
GO:0010986 (positive regulation of lipoprotein particle clearance)
GO:0015914 (phospholipid transport)
GO:0016032 (viral process)
GO:0030299 (intestinal cholesterol absorption)
GO:0030301 (cholesterol transport)
GO:0034381 (plasma lipoprotein particle clearance)
GO:0034382 (chylomicron remnant clearance)
GO:0034383 (low-density lipoprotein particle clearance)
GO:0042157 (lipoprotein metabolic process)
GO:0042159 (lipoprotein catabolic process)
GO:0042632 (cholesterol homeostasis)
GO:0045807 (positive regulation of endocytosis)
GO:0046718 (viral entry into host cell)
GO:0050729 (positive regulation of inflammatory response)
GO:0051246 (regulation of protein metabolic process)
GO:0051248 (negative regulation of protein metabolic process)
GO:0061024 (membrane organization)
GO:0061771 (response to caloric restriction)
GO:0061889 (negative regulation of astrocyte activation)
GO:0070508 (cholesterol import)
GO:0071398 (cellular response to fatty acid)
GO:0071404 (cellular response to low-density lipoprotein particle stimulus)
GO:0090118 (receptor-mediated endocytosis involved in cholesterol transport)
GO:0090181 (regulation of cholesterol metabolic process)
GO:0097242 (amyloid-beta clearance)
GO:1900223 (positive regulation of amyloid-beta clearance)
GO:1903979 (negative regulation of microglial cell activation)
GO:1905167 (positive regulation of lysosomal protein catabolic process)
GO:1905907 (negative regulation of amyloid fibril formation)
Wikipedia LDL_receptor

Target Cross References - Protein

canSAR P01130
CGD Hypercholesterolemia, familial
Human Protein Atlas ENSG00000130164
IntAct P01130
Open Targets ENSG00000130164
PharmGKB PA227
Reactome R-HSA-8856825 (Cargo recognition for clathrin-mediated endocytosis.)
R-HSA-8856828 (Clathrin-mediated endocytosis.)
R-HSA-8964026 (Chylomicron clearance.)
R-HSA-8964038 (LDL clearance.)
R-HSA-975634 (Retinoid metabolism and transport.)
UniProt B4DII3 B4DJZ8 B4DR00 B4DTQ3 C0JYY8 H0YLU8 H0YNT7 P01130 Q53ZD9 Q59FQ1 Q9UDH7

Target Cross References - Domain

InterPro IPR000033 (LDLR_classB_rpt.)
IPR000152 (EGF-type_Asp/Asn_hydroxyl_site.)
IPR000742 (EGF-like_dom.)
IPR001881 (EGF-like_Ca-bd_dom.)
IPR002172 (LDrepeatLR_classA_rpt.)
IPR009030 (Growth_fac_rcpt_cys_sf.)
IPR011042 (6-blade_b-propeller_TolB-like.)
IPR013032 (EGF-like_CS.)
IPR018097 (EGF_Ca-bd_CS.)
IPR023415 (LDLR_class-A_CS.)
IPR036055 (LDL_receptor-like_sf.)
Pfam PF00057 (Ldl_recept_a)
PF00058 (Ldl_recept_b)
PF07645 (EGF_CA)

Target Cross References - Structure

PDBe 1AJJ 1IJQ 1N7D 2FCW 2W2M 2W2N 2W2O 2W2P 2W2Q 3BPS 3GCW 3GCX 3M0C 3P5B 3P5C 3SO6 4NE9
CREDO 1AJJ 1IJQ 1N7D 2FCW 2W2M 2W2N 2W2O 2W2P 2W2Q 3BPS 3GCW 3GCX 3M0C 3P5B 3P5C 3SO6 4NE9