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Target Report Card

Target Name and Classification

Target ID CHEMBL3311
Preferred Name LDL receptor
Synonyms LDL receptor | LDLR | Low-density lipoprotein receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor

Target Components

Component Description Relationship Accession
Low-density lipoprotein receptor SINGLE PROTEIN P01130

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000130164
Ensembl ENSG00000130164
GO Cellular Component GO:0005764 (lysosome)
GO:0005768 (endosome)
GO:0005769 (early endosome)
GO:0005770 (late endosome)
GO:0005794 (Golgi apparatus)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0005905 (clathrin-coated pit)
GO:0009897 (external side of plasma membrane)
GO:0009986 (cell surface)
GO:0010008 (endosome membrane)
GO:0012505 (endomembrane system)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016323 (basolateral plasma membrane)
GO:0030669 (clathrin-coated endocytic vesicle membrane)
GO:0034362 (low-density lipoprotein particle)
GO:0043235 (receptor complex)
GO:0045177 (apical part of cell)
GO:1990666 (PCSK9-LDLR complex)
GO Molecular Function GO:0001618 (virus receptor activity)
GO:0001948 (glycoprotein binding)
GO:0002020 (protease binding)
GO:0004872 (receptor activity)
GO:0005041 (low-density lipoprotein receptor activity)
GO:0005509 (calcium ion binding)
GO:0005515 (protein binding)
GO:0030169 (low-density lipoprotein particle binding)
GO:0030229 (very-low-density lipoprotein particle receptor activity)
GO:0032050 (clathrin heavy chain binding)
GO:0042802 (identical protein binding)
GO Biological Process GO:0006629 (lipid metabolic process)
GO:0006810 (transport)
GO:0006869 (lipid transport)
GO:0006897 (endocytosis)
GO:0006898 (receptor-mediated endocytosis)
GO:0008202 (steroid metabolic process)
GO:0008203 (cholesterol metabolic process)
GO:0010867 (positive regulation of triglyceride biosynthetic process)
GO:0010899 (regulation of phosphatidylcholine catabolic process)
GO:0015914 (phospholipid transport)
GO:0016032 (viral process)
GO:0030299 (intestinal cholesterol absorption)
GO:0030301 (cholesterol transport)
GO:0034383 (low-density lipoprotein particle clearance)
GO:0042157 (lipoprotein metabolic process)
GO:0042159 (lipoprotein catabolic process)
GO:0042632 (cholesterol homeostasis)
GO:0046718 (viral entry into host cell)
GO:0070508 (cholesterol import)
GO:2000188 (regulation of cholesterol homeostasis)
Wikipedia LDL_receptor

Target Cross References - Protein

canSAR P01130
CGD Hypercholesterolemia, familial
Human Protein Atlas ENSG00000130164
IntAct P01130
Open Targets ENSG00000130164
PharmGKB PA227
Reactome R-HSA-171052 (LDL-mediated lipid transport.)
R-HSA-174800 (Chylomicron-mediated lipid transport.)
R-HSA-8856825 (Cargo recognition for clathrin-mediated endocytosis.)
R-HSA-8856828 (Clathrin-mediated endocytosis.)
R-HSA-975634 (Retinoid metabolism and transport.)
UniProt B4DII3 B4DJZ8 B4DR00 B4DTQ3 C0JYY8 H0YLU8 H0YNT7 P01130 Q53ZD9 Q59FQ1 Q9UDH7

Target Cross References - Domain

InterPro IPR000033 (LDLR_classB_rpt.)
IPR000152 (EGF-type_Asp/Asn_hydroxyl_site.)
IPR000742 (EGF-like_dom.)
IPR001881 (EGF-like_Ca-bd_dom.)
IPR002172 (LDrepeatLR_classA_rpt.)
IPR009030 (Growth_fac_rcpt_.)
IPR011042 (6-blade_b-propeller_TolB-like.)
IPR013032 (EGF-like_CS.)
IPR018097 (EGF_Ca-bd_CS.)
IPR023415 (LDLR_class-A_CS.)
Pfam PF00057 (Ldl_recept_a)
PF00058 (Ldl_recept_b)
PF07645 (EGF_CA)

Target Cross References - Structure

PDBe 1AJJ 1IJQ 1N7D 2FCW 2W2M 2W2N 2W2O 2W2P 2W2Q 3BPS 3GCW 3GCX 3M0C 3P5B 3P5C 3SO6 4NE9
CREDO 1AJJ 1IJQ 1N7D 2FCW 2W2M 2W2N 2W2O 2W2P 2W2Q 3BPS 3GCW 3GCX 3M0C 3P5B 3P5C 3SO6 4NE9