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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3308
Target Type SINGLE PROTEIN
Preferred Name Caspase-6
Synonyms Apoptotic protease Mch-2 | CASP-6 | CASP6 | Caspase-6 | Caspase-6 subunit p11 | Caspase-6 subunit p18 | MCH2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > cysteine protease > cysteine protease cd clan > cysteine protease c14 family

Target Components

Component Description Relationship Accession
Caspase-6 SINGLE PROTEIN P55212

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000138794
Ensembl ENSG00000138794
GO Cellular Component GO:0005654 (nucleoplasm)
GO:0005829 (cytosol)
GO Molecular Function GO:0004197 (cysteine-type endopeptidase activity)
GO:0005515 (protein binding)
GO Biological Process GO:0006508 (proteolysis)
GO:0006917 (induction of apoptosis)
GO:0006921 (cellular component disassembly involved in apoptosis)
Wikipedia Caspase_6

Target Cross References - Protein

canSAR P55212
Human Protein Atlas ENSG00000138794
IntAct P55212
Guide to Pharmacology 1622 (Caspase 6)
PharmGKB PA26090
Reactome REACT_578 (Apoptosis.)
UniProt P55212 Q9BQE7

Target Cross References - Domain

InterPro IPR001309 (Pept_C14_ICE_p20.)
IPR002138 (Pept_C14_p10.)
IPR002398 (Pept_C14_p45.)
IPR011600 (Pept_C14_cat.)
IPR015469 (Caspase_6.)
IPR015917 (Pept_C14_p45_core.)
IPR016129 (Pept_C14_ICE_p20_AS.)
Pfam PF00656 (Peptidase_C14)

Target Cross References - Structure

PDBe 2WDP 3K7E 3NKF 3NR2 3OD5
CREDO 2WDP 3K7E 3NKF 3NR2 3OD5
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