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Target Report Card

Target Name and Classification

Target ID CHEMBL3298
Target Type SINGLE PROTEIN
Preferred Name Alpha enolase
Synonyms 2-phospho-D-glycerate hydro-lyase | Alpha-enolase | C-myc promoter-binding protein | ENO1 | ENO1L1 | Enolase 1 | MBP-1 | MBPB1 | MPB-1 | MPB1 | NNE | Non-neural enolase | Phosphopyruvate hydratase | Plasminogen-binding protein
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Alpha-enolase SINGLE PROTEIN P06733

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000074800
Ensembl ENSG00000074800
GO Cellular Component GO:0000015 (phosphopyruvate hydratase complex)
GO:0005615 (extracellular space)
GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0019897 (extrinsic component of plasma membrane)
GO:0031430 (M band)
GO:0043209 (myelin sheath)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0000287 (magnesium ion binding)
GO:0003677 (DNA binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0003714 (transcription corepressor activity)
GO:0003723 (RNA binding)
GO:0004634 (phosphopyruvate hydratase activity)
GO:0005515 (protein binding)
GO:0016829 (lyase activity)
GO:0044822 (poly(A) RNA binding)
GO:0046872 (metal ion binding)
GO:0046982 (protein heterodimerization activity)
GO:0051020 (GTPase binding)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0001701 (in utero embryonic development)
GO:0006094 (gluconeogenesis)
GO:0006096 (glycolytic process)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0009615 (response to virus)
GO:0030308 (negative regulation of cell growth)
GO:0045892 (negative regulation of transcription, DNA-templated)
GO:0051099 (positive regulation of binding)
GO:0061621 (canonical glycolysis)
Wikipedia Alpha-enolase

Target Cross References - Protein

canSAR P06733
Human Protein Atlas ENSG00000074800
IntAct P06733
Open Targets ENSG00000074800
PharmGKB PA27786
Reactome R-HSA-70171 (Glycolysis.)
R-HSA-70263 (Gluconeogenesis.)
UniProt B2RD59 P06733 P22712 Q16704 Q4TUS4 Q53FT9 Q53HR3 Q658M5 Q6GMP2 Q71V37 Q7Z3V6 Q8WU71 Q96GV1 Q9BT62 Q9UCH6 Q9UM55

Target Cross References - Domain

InterPro IPR000941 (Enolase.)
IPR020809 (Enolase_CS.)
IPR020810 (Enolase_C.)
IPR020811 (Enolase_N.)
IPR029017 (Enolase_N-like.)
IPR029065 (Enolase_C-like.)
Pfam PF00113 (Enolase_C)
PF03952 (Enolase_N)

Target Cross References - Structure

PDBe 2PSN 3B97 5JLZ 5LAX
CREDO 2PSN 3B97 5JLZ 5LAX
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