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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3291
Target Type SINGLE PROTEIN
Preferred Name Phosphofructokinase muscle type
Synonyms 6-phosphofructokinase type A | ATP-PFK | ATP-dependent 6-phosphofructokinase, muscle type | PFK-A | PFK-M | PFKM | PFKX | Phosphofructo-1-kinase isozyme A | Phosphohexokinase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
ATP-dependent 6-phosphofructokinase, muscle type SINGLE PROTEIN P08237

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000152556
Ensembl ENSG00000152556
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005945 (6-phosphofructokinase complex)
GO:0016324 (apical plasma membrane)
GO:0070062 (extracellular exosome)
GO:0097228 (sperm principal piece)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0003824 (catalytic activity)
GO:0003872 (6-phosphofructokinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0008022 (protein C-terminus binding)
GO:0008443 (phosphofructokinase activity)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0019900 (kinase binding)
GO:0042802 (identical protein binding)
GO:0042803 (protein homodimerization activity)
GO:0046872 (metal ion binding)
GO:0070061 (fructose binding)
GO Biological Process GO:0005980 (glycogen catabolic process)
GO:0006002 (fructose 6-phosphate metabolic process)
GO:0006096 (glycolytic process)
GO:0008152 (metabolic process)
GO:0016310 (phosphorylation)
GO:0032024 (positive regulation of insulin secretion)
GO:0042593 (glucose homeostasis)
GO:0046716 (muscle cell cellular homeostasis)
GO:0046835 (carbohydrate phosphorylation)
GO:0051259 (protein oligomerization)
GO:0061615 (glycolytic process through fructose-6-phosphate)
GO:0061621 (canonical glycolysis)
GO:0093001 (glycolysis from storage polysaccharide through glucose-1-phosphate)
Wikipedia PFKM

Target Cross References - Protein

canSAR P08237
CGD Glycogen storage disease VII
Human Protein Atlas ENSG00000152556
IntAct P08237
Open Targets ENSG00000152556
PharmGKB PA33216
Reactome R-HSA-70171 (Glycolysis.)
UniProt J3KNX3 P08237 Q16814 Q16815 Q6ZTT1

Target Cross References - Domain

InterPro IPR000023 (Phosphofructokinase_dom.)
IPR009161 (6-Pfructokinase_euk.)
IPR015912 (Phosphofructokinase_CS.)
IPR022953 (ATP_PFK.)
Pfam PF00365 (PFK)

Target Cross References - Structure

PDBe 4OMT
CREDO 4OMT
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