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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3277
Target Type SINGLE PROTEIN
Preferred Name Uracil-DNA glycosylase
Synonyms DGU | UDG | UNG | UNG1 | UNG15 | Uracil-DNA glycosylase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Uracil-DNA glycosylase SINGLE PROTEIN P13051

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000076248
Ensembl ENSG00000076248
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005739 (mitochondrion)
GO Molecular Function GO:0003684 (damaged DNA binding)
GO:0004844 (uracil DNA N-glycosylase activity)
GO:0005515 (protein binding)
GO:0016787 (hydrolase activity)
GO:0016798 (hydrolase activity, acting on glycosyl bonds)
GO:0016799 (hydrolase activity, hydrolyzing N-glycosyl compounds)
GO:0019899 (enzyme binding)
GO Biological Process GO:0006281 (DNA repair)
GO:0006284 (base-excision repair)
GO:0006974 (cellular response to DNA damage stimulus)
GO:0008152 (metabolic process)
GO:0016032 (viral process)
GO:0016446 (somatic hypermutation of immunoglobulin genes)
GO:0016447 (somatic recombination of immunoglobulin gene segments)
GO:0043066 (negative regulation of apoptotic process)
GO:0045008 (depyrimidination)
GO:0045830 (positive regulation of isotype switching)
GO:0097510 (base-excision repair, AP site formation via deaminated base removal)
Wikipedia Uracil-DNA_glycosylase

Target Cross References - Protein

canSAR P13051
CGD Immunodeficiency with hyper-IgM, type 5
Human Protein Atlas ENSG00000076248
IntAct P13051
Open Targets ENSG00000076248
PharmGKB PA364
Reactome R-HSA-110328 (Recognition and association of DNA glycosylase with site containing an affected pyrimidine.)
R-HSA-110329 (Cleavage of the damaged pyrimidine.)
R-HSA-110357 (Displacement of DNA glycosylase by APEX1.)
UniProt A8K5M6 B2R8Y1 O00637 O00719 P13051 Q93028

Target Cross References - Domain

InterPro IPR002043 (UDG_fam1.)
IPR005122 (Uracil-DNA_glycosylase-like.)
IPR018085 (Ura-DNA_Glyclase_AS.)
Pfam PF03167 (UDG)

Target Cross References - Structure

PDBe 1AKZ 1EMH 1EMJ 1Q3F 1SSP 1UGH 1YUO 2HXM 2OXM 2OYT 2SSP 3FCF 3FCI 3FCK 3FCL 3TKB 4SKN 5AYR 5JK7
CREDO 1AKZ 1EMH 1EMJ 1Q3F 1SSP 1UGH 1YUO 2HXM 2OXM 2OYT 2SSP 3FCF 3FCI 3FCK 3FCL 3TKB 4SKN 5AYR 5JK7
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