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Target Report Card

Target Name and Classification

Target ID CHEMBL3273
Preferred Name Sodium/hydrogen exchanger 3
Synonyms NHE-3 | NHE3 | Na(+)/H(+) exchanger 3 | SLC9A3 | Sodium/hydrogen exchanger 3 | Solute carrier family 9 member 3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transporter > electrochemical transporter > slc superfamily of solute carriers > slc09 family of sodium/hydrogen exchangers

Target Components

Component Description Relationship Accession
Sodium/hydrogen exchanger 3 SINGLE PROTEIN P48764

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000066230
Ensembl ENSG00000066230
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005903 (brush border)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016324 (apical plasma membrane)
GO:0031526 (brush border membrane)
GO:0031988 (membrane-bounded vesicle)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0005515 (protein binding)
GO:0015297 (antiporter activity)
GO:0015299 (solute:proton antiporter activity)
GO:0015385 (sodium:proton antiporter activity)
GO:0015386 (potassium:proton antiporter activity)
GO:0030165 (PDZ domain binding)
GO Biological Process GO:0002028 (regulation of sodium ion transport)
GO:0006810 (transport)
GO:0006811 (ion transport)
GO:0006812 (cation transport)
GO:0006814 (sodium ion transport)
GO:0006885 (regulation of pH)
GO:0006898 (receptor-mediated endocytosis)
GO:0007623 (circadian rhythm)
GO:0035725 (sodium ion transmembrane transport)
GO:0051384 (response to glucocorticoid)
GO:0051453 (regulation of intracellular pH)
GO:0055085 (transmembrane transport)
GO:0071805 (potassium ion transmembrane transport)
GO:0098719 (sodium ion import across plasma membrane)
GO:1902600 (hydrogen ion transmembrane transport)
Wikipedia Sodium%E2%80%93hydrogen_antiporter_3

Target Cross References - Protein

canSAR P48764
Human Protein Atlas ENSG00000066230
IntAct P48764
Open Targets ENSG00000066230
PharmGKB PA316
Reactome R-HSA-425986 (Sodium/Proton exchangers.)
UniProt B7ZKR2 E9PF67 P48764 Q3MIW3

Target Cross References - Domain

InterPro IPR004709 (NaH_exchanger.)
IPR006153 (Cation/H_exchanger.)
IPR018410 (Na/H_exchanger_3/5.)
IPR018422 (Cation/H_exchanger_CPA1.)
Pfam PF00999 (Na_H_Exchanger)